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    serpinb14 serpin peptidase inhibitor, clade B (ovalbumin), member 14 [ Danio rerio (zebrafish) ]

    Gene ID: 569051, updated on 9-Dec-2024

    Summary

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    Official Symbol
    serpinb14provided by ZNC
    Official Full Name
    serpin peptidase inhibitor, clade B (ovalbumin), member 14provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050506-148
    See related
    Ensembl:ENSDARG00000091801 AllianceGenome:ZFIN:ZDB-GENE-050506-148
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7148243; si:ch73-303g23.4
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91 and peeling skin syndrome 5. Orthologous to several human genes including SERPINB8 (serpin family B member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See serpinb14 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (51243963..51254567, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (51380005..51390741, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:ch73-52f24.4 Neighboring gene high mobility group nucleosomal binding domain 2 Neighboring gene serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 1 Neighboring gene uncharacterized LOC137487989

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte elastase inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      51243963..51254567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002665065.7 → XP_002665111.3  leukocyte elastase inhibitor

      See identical proteins and their annotated locations for XP_002665111.3

      UniProtKB/TrEMBL
      A0A8M1RE37, E7EXC4, F8W412
      Related
      ENSDARP00000124283.1, ENSDART00000148894.2
      Conserved Domains (1) summary
      cl00137
      Location:4 → 437
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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