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    zp3a.2 zona pellucida glycoprotein 3a, tandem duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 558677, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zp3a.2provided by ZNC
    Official Full Name
    zona pellucida glycoprotein 3a, tandem duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040727-2
    See related
    Ensembl:ENSDARG00000042130 AllianceGenome:ZFIN:ZDB-GENE-040727-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zp3al; zpc1-2; fj87h02; wu:fj87h02; zgc:153827; si:dkey-51e6none
    Summary
    Predicted to enable acrosin binding activity. Predicted to be involved in binding activity of sperm to zona pellucida; egg coat formation; and positive regulation of acrosome reaction. Predicted to be located in egg coat; extracellular region; and plasma membrane. Predicted to be active in extracellular matrix. Orthologous to several human genes including ZP3 (zona pellucida glycoprotein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zp3a.2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (33987465..33989427)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (34084586..34086548)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene selectin E Neighboring gene si:dkey-51e6.1 Neighboring gene zona pellucida glycoprotein 3a, tandem duplicate 1 Neighboring gene fignl1 interacting regulator of recombination and mitosis

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Functional visualization and disruption of targeted genes using CRISPR/Cas9-mediated eGFP reporter integration in zebrafish. Ota S, et al. Sci Rep, 2016 Oct 11. PMID 27725766, Free PMC Article
    2. Tandem-repeated Zebrafish zp3 genes possess oocyte-specific promoters and are insensitive to estrogen induction. Liu X, et al. Biol Reprod, 2006 Jun. PMID 16481590
    3. Induced autoimmunity against gonadal proteins affects gonadal development in juvenile zebrafish. Presslauer C, et al. PLoS One, 2014. PMID 25436775, Free PMC Article
    4. Bioinformatic analyses of zona pellucida genes in vertebrates and their expression in Nile tilapia. Wu T, et al. Fish Physiol Biochem, 2018 Apr. PMID 29307115
    5. Lamprey IGF-Binding Protein-3 Has IGF-Dependent and -Independent Actions. Zhong Y, et al. Front Endocrinol (Lausanne), 2016. PMID 28149290, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acrosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of egg coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in egg coat formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of acrosome reaction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in egg coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zona pellucida sperm-binding protein 3a.2
    Names
    zona pellucida glycoprotein 3a.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030120.1 → NP_001025291.1  zona pellucida sperm-binding protein 3a.2 precursor

      See identical proteins and their annotated locations for NP_001025291.1

      Status: PROVISIONAL

      Source sequence(s)
      CR318619
      UniProtKB/TrEMBL
      A4FUK0, Q5TYP2
      Related
      ENSDARP00000061750.5, ENSDART00000061751.6
      Conserved Domains (2) summary
      smart00241
      Location:116 → 372
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:234 → 371
      Zona_pellucida; Zona pellucida-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      33987465..33989427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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