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    myo18ab myosin XVIIIA b [ Danio rerio (zebrafish) ]

    Gene ID: 559005, updated on 9-Dec-2024

    Summary

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    Official Symbol
    myo18abprovided by ZNC
    Official Full Name
    myosin XVIIIA bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080423-1
    See related
    Ensembl:ENSDARG00000061862 AllianceGenome:ZFIN:ZDB-GENE-080423-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tiaf1; myo18l1; wu:fb52c07; si:ch211-103e6.2
    Summary
    Predicted to enable actin filament binding activity. Acts upstream of or within several processes, including Golgi organization; muscle tissue morphogenesis; and striated muscle cell development. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in head; notochord; skeletal muscle cell; and somite. Orthologous to human MYO18A (myosin XVIIIA). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See myo18ab in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (23947959..24120972)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (24012681..24185652)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:ch1073-145m9.1 Neighboring gene amyloid beta precursor protein (cytoplasmic tail) binding protein 2 Neighboring gene pipecolic acid oxidase Neighboring gene seizure related 6 homolog b Neighboring gene uncharacterized LOC108179305

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The PDZ-containing unconventional myosin XVIIIA regulates embryonic muscle integrity in zebrafish. Cao J, et al. J Genet Genomics, 2014 Aug 20. PMID 25160974
    2. Identification of novel MYO18A interaction partners required for myoblast adhesion and muscle integrity. Cao JM, et al. Sci Rep, 2016 Nov 8. PMID 27824130, Free PMC Article
    3. Genome wide association and genomic prediction for growth traits in juvenile farmed Atlantic salmon using a high density SNP array. Tsai HY, et al. BMC Genomics, 2015 Nov 18. PMID 26582102, Free PMC Article
    4. Expression of unconventional myosin genes during neuronal development in zebrafish. Sittaramane V, et al. Gene Expr Patterns, 2008 Feb. PMID 18078791, Free PMC Article
    5. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-matrix adhesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle tissue morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle fiber development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin-XVIIIa; unconventional myosin-XVIIIa
    Names
    TGFB1-induced anti-apoptotic factor 1
    myo18a
    myosin XVIII-like 1
    myosin XVIIIAb

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      23947959..24120972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213726.1 → XP_068069827.1  unconventional myosin-XVIIIa isoform X1

      UniProtKB/TrEMBL
      A0A8M9NYM9

    2. XM_068213735.1 → XP_068069836.1  unconventional myosin-XVIIIa isoform X9

    3. XM_068213745.1 → XP_068069846.1  unconventional myosin-XVIIIa isoform X19

    4. XM_068213736.1 → XP_068069837.1  unconventional myosin-XVIIIa isoform X10

      UniProtKB/TrEMBL
      A0A8M3APY2

    5. XM_068213737.1 → XP_068069838.1  unconventional myosin-XVIIIa isoform X11

      UniProtKB/TrEMBL
      A0A8M3APY2
      Related
      ENSDARP00000128019.1, ENSDART00000153951.3

    6. XM_068213738.1 → XP_068069839.1  unconventional myosin-XVIIIa isoform X12

      UniProtKB/TrEMBL
      A0A8M3AHI6

    7. XM_068213739.1 → XP_068069840.1  unconventional myosin-XVIIIa isoform X13

      UniProtKB/TrEMBL
      A0A8M9PIP0

    8. XM_068213740.1 → XP_068069841.1  unconventional myosin-XVIIIa isoform X14

      UniProtKB/TrEMBL
      A0A8M6YT96

    9. XM_068213725.1 → XP_068069826.1  unconventional myosin-XVIIIa isoform X1

      UniProtKB/TrEMBL
      A0A8M9NYM9

    10. XM_068213741.1 → XP_068069842.1  unconventional myosin-XVIIIa isoform X15

      UniProtKB/TrEMBL
      A0A8M9NYM9, A0A8M9P7A8

    11. XM_068213730.1 → XP_068069831.1  unconventional myosin-XVIIIa isoform X4

      UniProtKB/TrEMBL
      A0A8M9NYM9

    12. XM_068213742.1 → XP_068069843.1  unconventional myosin-XVIIIa isoform X16

      UniProtKB/TrEMBL
      A0A8M9NYM9, A0A8M9PCE1

    13. XM_068213728.1 → XP_068069829.1  unconventional myosin-XVIIIa isoform X2

      UniProtKB/TrEMBL
      A0A8M9NYM9

    14. XM_068213731.1 → XP_068069832.1  unconventional myosin-XVIIIa isoform X5

      UniProtKB/TrEMBL
      A0A8M9NYM9

    15. XM_068213729.1 → XP_068069830.1  unconventional myosin-XVIIIa isoform X3

      UniProtKB/TrEMBL
      A0A8M9NYM9

    16. XM_068213732.1 → XP_068069833.1  unconventional myosin-XVIIIa isoform X6

      UniProtKB/TrEMBL
      A0A8M9NYM9

    17. XM_068213733.1 → XP_068069834.1  unconventional myosin-XVIIIa isoform X7

      UniProtKB/TrEMBL
      A0A8M9NYM9

    18. XM_068213734.1 → XP_068069835.1  unconventional myosin-XVIIIa isoform X8

      UniProtKB/TrEMBL
      A0A8M9PLN0

    19. XM_068213743.1 → XP_068069844.1  unconventional myosin-XVIIIa isoform X17

    20. XM_068213727.1 → XP_068069828.1  unconventional myosin-XVIIIa isoform X1

      UniProtKB/TrEMBL
      A0A8M9NYM9
      Related
      ENSDARP00000083081.5, ENSDART00000088648.6

    21. XM_068213744.1 → XP_068069845.1  unconventional myosin-XVIIIa isoform X18

    Nucleotide Protein Strain
    Heading Accession and Version

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