shmt2 serine hydroxymethyltransferase 2 (mitochondrial) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: shmt2provided by ZNC
Official Full Name: serine hydroxymethyltransferase 2 (mitochondrial)provided by ZNC
Primary source: ZFIN:ZDB-GENE-071213-1
See related: Ensembl:ENSDARG00000104414 AllianceGenome:ZFIN:ZDB-GENE-071213-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables glycine hydroxymethyltransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in glycine biosynthetic process from serine and tetrahydrofolate metabolic process. Predicted to act upstream of or within methylation and one-carbon metabolic process. Located in mitochondrion. Is expressed in digestive system; heart; muscle; nervous system; and pleuroperitoneal region. Used to study schizophrenia. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities. Orthologous to human SHMT2 (serine hydroxymethyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (59176470..59230818)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (59182239..59235373)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glycine hydroxymethyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine hydroxymethyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine hydroxymethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycine biosynthetic process from serine	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycine biosynthetic process from serine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tetrahydrofolate interconversion	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolate interconversion	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine hydroxymethyltransferase, mitochondrial

Names: mitochondrial serine hydroxymethyltransferase

NP_001116846.1

EC 2.1.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001123374.1 → NP_001116846.1 serine hydroxymethyltransferase, mitochondrial

See identical proteins and their annotated locations for NP_001116846.1

Status: PROVISIONAL

Source sequence(s)

EF213101

UniProtKB/TrEMBL

A0A0R4IBM1, A0A8M1NG89, A9LDD9

Related

ENSDARP00000132340.2, ENSDART00000161720.2

Conserved Domains (2) summary

PLN03226
Location:34 → 489

PLN03226; serine hydroxymethyltransferase; Provisional

pfam00464
Location:38 → 436

SHMT; Serine hydroxymethyltransferase