sec24c SEC24 homolog C, COPII coat complex component [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sec24cprovided by ZNC
Official Full Name: SEC24 homolog C, COPII coat complex componentprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4487
See related: Ensembl:ENSDARG00000103516 AllianceGenome:ZFIN:ZDB-GENE-030131-4487
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7145364; wu:fd10d12
Summary: Predicted to enable SNARE binding activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to act upstream of or within endoplasmic reticulum to Golgi vesicle-mediated transport and intracellular protein transport. Predicted to be located in cytoplasmic vesicle; cytosol; and endoplasmic reticulum membrane. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in gut and head. Orthologous to human SEC24C (SEC24 homolog C, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (35543160..35582523, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (35442097..35481458, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fd10d12.x1 (e-PCR)
- UniSTS:195109

fi17a01.x1 (e-PCR)
- UniSTS:196918

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in COPII-coated vesicle cargo loading	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COPII vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPII vesicle coat	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein transport protein Sec24C

Names: SEC24 family, member C; SEC24-related protein C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001245968.3 → NP_001232897.3 protein transport protein Sec24C

Status: VALIDATED

Source sequence(s)

CU469520, CU694198

UniProtKB/TrEMBL

A0A0R4IMX2, A0A8M1NZ87

Related

ENSDARP00000135644.1, ENSDART00000162175.2

Conserved Domains (8) summary

COG5028
Location:380 → 1244

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

cd01479
Location:653 → 897

Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...

pfam02084
Location:13 → 95

Bindin; Bindin

pfam00626
Location:1118 → 1190

Gelsolin; Gelsolin repeat

pfam03957
Location:151 → 250

Jun; Jun-like transcription factor

pfam04810
Location:576 → 613

zf-Sec23_Sec24; Sec23/Sec24 zinc finger

pfam04815
Location:1001 → 1097

Sec23_helical; Sec23/Sec24 helical domain

pfam08033
Location:902 → 985

Sec23_BS; Sec23/Sec24 beta-sandwich domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

35543160..35582523 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005156360.5 → XP_005156417.2 protein transport protein Sec24C isoform X4

UniProtKB/TrEMBL

A0A8M2B330

Conserved Domains (8) summary

COG5028
Location:380 → 1267

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

cd01479
Location:676 → 920

Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...

pfam02084
Location:13 → 95

Bindin; Bindin

pfam00626
Location:1141 → 1213

Gelsolin; Gelsolin repeat

pfam03957
Location:151 → 250

Jun; Jun-like transcription factor

pfam04810
Location:599 → 636

zf-Sec23_Sec24; Sec23/Sec24 zinc finger

pfam04815
Location:1024 → 1120

Sec23_helical; Sec23/Sec24 helical domain

pfam08033
Location:925 → 1008

Sec23_BS; Sec23/Sec24 beta-sandwich domain
XM_005156359.5 → XP_005156416.2 protein transport protein Sec24C isoform X3

UniProtKB/TrEMBL

A0A8M2B375

Conserved Domains (7) summary

COG5028
Location:409 → 1273

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

cd01479
Location:682 → 926

Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...

pfam00626
Location:1147 → 1219

Gelsolin; Gelsolin repeat

pfam03957
Location:180 → 279

Jun; Jun-like transcription factor

pfam04810
Location:605 → 642

zf-Sec23_Sec24; Sec23/Sec24 zinc finger

pfam04815
Location:1030 → 1126

Sec23_helical; Sec23/Sec24 helical domain

pfam08033
Location:931 → 1014

Sec23_BS; Sec23/Sec24 beta-sandwich domain
XM_017358478.3 → XP_017213967.1 protein transport protein Sec24C isoform X2

UniProtKB/TrEMBL

A0A8M6Z9C2
XM_005156357.5 → XP_005156414.2 protein transport protein Sec24C isoform X1

UniProtKB/TrEMBL

A0A0R4IAZ9, A0A8M2B2P6

Related

ENSDARP00000130259.1, ENSDART00000167933.2

Conserved Domains (7) summary

COG5028
Location:409 → 1296

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

cd01479
Location:705 → 949

Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...

pfam00626
Location:1170 → 1242

Gelsolin; Gelsolin repeat

pfam03957
Location:180 → 279

Jun; Jun-like transcription factor

pfam04810
Location:628 → 665

zf-Sec23_Sec24; Sec23/Sec24 zinc finger

pfam04815
Location:1053 → 1149

Sec23_helical; Sec23/Sec24 helical domain

pfam08033
Location:954 → 1037

Sec23_BS; Sec23/Sec24 beta-sandwich domain