gfm2 GTP dependent ribosome recycling factor mitochondrial 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gfm2provided by ZNC
Official Full Name: GTP dependent ribosome recycling factor mitochondrial 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-060201-3
See related: Ensembl:ENSDARG00000005561 AllianceGenome:ZFIN:ZDB-GENE-060201-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: RRF2mt; EF-G2mt; mEF-G 2; zgc:153835; si:dkey-35i22.3
Summary: Predicted to enable GTPase activity. Predicted to be involved in mitochondrial translation and ribosome disassembly. Predicted to act upstream of or within translation. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 39. Orthologous to human GFM2 (GTP dependent ribosome recycling factor mitochondrial 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (34578570..34600710)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (33978417..34000557)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosome disassembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ribosome disassembly	IEA Inferred from Electronic Annotation more info
involved_in ribosome disassembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosome-releasing factor 2, mitochondrial

Names: G elongation factor, mitochondrial 2

NP_001071013.1

EC 3.6.5.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077545.1 → NP_001071013.1 ribosome-releasing factor 2, mitochondrial

See identical proteins and their annotated locations for NP_001071013.1

Status: PROVISIONAL

Source sequence(s)

BC125896

UniProtKB/Swiss-Prot

A0JMI9, A2BHE0, Q4VBG9

Related

ENSDARP00000006504.9, ENSDART00000016314.10

Conserved Domains (6) summary

cd01886
Location:58 → 340

EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis

PRK12739
Location:52 → 760

PRK12739; elongation factor G; Reviewed

cd01693
Location:546 → 665

mtEFG2_like_IV; mtEF-G2 domain IV. This subfamily is a part the of mitochondrial transcriptional elongation factor, mtEF-G2. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory ...

cd03713
Location:670 → 746

EFG_mtEFG_C; EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2 ...

cd04092
Location:355 → 437

mtEFG2_II_like; Domain II of mitochondrial elongation factor G2-like proteins found in eukaryotes

cd16262
Location:470 → 545

EFG_III; Domain III of Elongation Factor G (EFG)