srd5a3 steroid 5 alpha-reductase 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: srd5a3provided by ZNC
Official Full Name: steroid 5 alpha-reductase 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7915
See related: Ensembl:ENSDARG00000043307 AllianceGenome:ZFIN:ZDB-GENE-030131-7915
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: S5AR 3; fj40g12; srd5a2l; wu:fj40g12; si:ch211-278f21.3
Summary: Predicted to enable 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity and polyprenol reductase activity. Predicted to be involved in dolichol biosynthetic process; dolichol-linked oligosaccharide biosynthetic process; and polyprenol catabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Kahrizi syndrome and congenital disorder of glycosylation Iq. Orthologous to human SRD5A3 (steroid 5 alpha-reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (22194318..22198982, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (22294645..22299309, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	ISS Inferred from Sequence or Structural Similarity more info
enables polyprenol reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables polyprenol reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dolichol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dolichol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in dolichol-linked oligosaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dolichol-linked oligosaccharide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dolichol-linked oligosaccharide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in polyprenol catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: polyprenal reductase

Names: 3-oxo-5-alpha-steroid 4-dehydrogenase 3; SR type 3; polyprenol reductase; probable polyprenol reductase

NP_001038404.1

EC 1.3.1.22

EC 1.3.1.94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

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These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.