jam2a junctional adhesion molecule 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: jam2aprovided by ZNC
Official Full Name: junctional adhesion molecule 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031204-3
See related: Ensembl:ENSDARG00000058996 AllianceGenome:ZFIN:ZDB-GENE-031204-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: jam2; JAM-B; sb:cb1002
Summary: Enables protein heterodimerization activity. Involved in regulation of skeletal muscle fiber development. Acts upstream of or within with a positive effect on myoblast fusion. Acts upstream of or within hematopoietic or lymphoid organ development. Predicted to be located in membrane. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in cell surface; plasma membrane; and tight junction. Is expressed in several structures, including blood vessel; musculature system; myoblast; nervous system; and pectoral fin bud. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (594637..608235)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (599458..613056)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicate that Jam1a-Jam2a interactions facilitate the transduction of requisite Notch signals from the somite to the precursors of HSCs, and that these events occur well before formation of the dorsal aorta
Title: Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling.
interaction between Jamb and Jamc expressed by neighbouring cells is essential for fusion.
Title: Jamb and jamc are essential for vertebrate myocyte fusion.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

fc73h01.x1 (e-PCR)
- UniSTS:194410

G46460 (e-PCR)
- UniSTS:107262

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within hematopoietic or lymphoid organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myoblast fusion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein complex involved in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in tight junction	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: junctional adhesion molecule 2A

Names: jamb; jamb.1; junctional adhesion molecule 2; junctional adhesion molecule B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098264.1 → NP_001091734.1 junctional adhesion molecule 2A precursor

See identical proteins and their annotated locations for NP_001091734.1

Status: PROVISIONAL

Source sequence(s)

CU458944

UniProtKB/Swiss-Prot

A0A0R4IGV4

UniProtKB/TrEMBL

A4JYM3

Related

ENSDARP00000132646.2, ENSDART00000166731.2

Conserved Domains (3) summary

smart00410
Location:26 → 119

IG_like; Immunoglobulin like

pfam13895
Location:129 → 211

Ig_2; Immunoglobulin domain

cl11960
Location:28 → 123

Ig; Immunoglobulin domain