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    mybpc2b myosin binding protein Cb [ Danio rerio (zebrafish) ]

    Gene ID: 541384, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mybpc2bprovided by ZNC
    Official Full Name
    myosin binding protein Cbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050320-80
    See related
    Ensembl:ENSDARG00000021265 AllianceGenome:ZFIN:ZDB-GENE-050320-80
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7137115; im:7150089; zgc:110761
    Summary
    Acts upstream of or within muscle tissue development. Predicted to be active in M band. Is expressed in several structures, including adaxial cell; musculature system; otic placode; otic vesicle; and trunk. Used to study myopathy. Orthologous to human MYBPC2 (myosin binding protein C2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mybpc2b in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (38259603..38348805)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (38371559..38460935)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene zgc:91999 Neighboring gene leucine rich repeat containing 4Bb Neighboring gene uncharacterized LOC108179067

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model. Da'as SI, et al. Int J Mol Sci, 2022 Aug 9. PMID 36012114, Free PMC Article
    2. Knockdown of fast skeletal myosin-binding protein C in zebrafish results in a severe skeletal myopathy. Li M, et al. J Gen Physiol, 2016 Apr. PMID 27022191, Free PMC Article
    3. Copper ions impair zebrafish skeletal myofibrillogenesis via epigenetic regulation. Jin X, et al. FASEB J, 2021 Jul. PMID 34101239
    4. Hypoxia-induced changes in the zebrafish (Danio rerio) skeletal muscle proteome. Chen K, et al. J Proteomics, 2013 Jan 14. PMID 23117182
    5. The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Hawkins TA, et al. Development, 2008 Mar. PMID 18256191, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. lack of MyBPC-2 results in a severe skeletal myopathy, elevated apoptosis and shorter sarcomeres.
      Title: Knockdown of fast skeletal myosin-binding protein C in zebrafish results in a severe skeletal myopathy.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myosin binding protein Cb
    Names
    myosin binding protein C, fast type b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013511.2 → NP_001013529.2  myosin binding protein Cb

      Status: PROVISIONAL

      Source sequence(s)
      BC091662, CK677061, CK677308, EB776017, EB790963, EB866488, EE327610, EE714531, EE714901, EE719585
      UniProtKB/TrEMBL
      A0A8M1N4T5, A0A8M9PLR4
      Conserved Domains (7) summary
      cd00096
      Location:1032 → 1097
      Ig; Immunoglobulin domain
      cd05748
      Location:822 → 894
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd05894
      Location:515 → 600
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:518 → 600
      IG_like; Immunoglobulin like
      cd00063
      Location:604 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1013 → 1102
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:224 → 295
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      38259603..38348805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217065.1 → XP_068073166.1  myosin binding protein Cb isoform X2

      UniProtKB/TrEMBL
      A0A8M6YW81
      Related
      ENSDARP00000096449.5, ENSDART00000105672.5

    2. XM_021470160.2 → XP_021325835.1  myosin binding protein Cb isoform X1

      UniProtKB/TrEMBL
      A0A8M6YW81, A0A8M9PXG3
      Conserved Domains (6) summary
      cd05894
      Location:508 → 593
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:26 → 121
      IG_like; Immunoglobulin like
      cd00063
      Location:597 → 683
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1006 → 1095
      I-set; Immunoglobulin I-set domain
      cd05748
      Location:815 → 887
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains
      cl28434
      Location:397 → 468
      I-set; Immunoglobulin I-set domain

    3. XM_068217066.1 → XP_068073167.1  myosin binding protein Cb isoform X2

      UniProtKB/TrEMBL
      A0A8M6YW81

    4. XM_021470162.2 → XP_021325837.1  myosin binding protein Cb isoform X3

      UniProtKB/TrEMBL
      A0A8M9P5V8, A0A8M9PU17
      Related
      ENSDARP00000115895.1, ENSDART00000143184.2
      Conserved Domains (6) summary
      cd05894
      Location:507 → 592
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:25 → 120
      IG_like; Immunoglobulin like
      cd00063
      Location:596 → 682
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1005 → 1094
      I-set; Immunoglobulin I-set domain
      cd05748
      Location:814 → 886
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains
      cl28434
      Location:396 → 467
      I-set; Immunoglobulin I-set domain
    Nucleotide Protein Strain
    Heading Accession and Version

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