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    rgl2 ral guanine nucleotide dissociation stimulator-like 2 [ Danio rerio (zebrafish) ]

    Gene ID: 65227, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rgl2provided by ZNC
    Official Full Name
    ral guanine nucleotide dissociation stimulator-like 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010131-1
    See related
    Ensembl:ENSDARG00000007727 AllianceGenome:ZFIN:ZDB-GENE-010131-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rab2l; im:7136742
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in plasma membrane. Orthologous to human RGL2 (ral guanine nucleotide dissociation stimulator like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rgl2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (45358955..45417216, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (45397663..45450694, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:dkey-33i11.1 Neighboring gene uncharacterized LOC137487976 Neighboring gene deoxyribonuclease II, lysosomal Neighboring gene synaptic Ras GTPase activating protein 1b Neighboring gene PHD finger protein 1 Neighboring gene SMG5 nonsense mediated mRNA decay factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary history of the ABCB2 genomic region in teleosts. Palti Y, et al. Dev Comp Immunol, 2007. PMID 17055577
    2. Conservation of Mhc class III region synteny between zebrafish and human as determined by radiation hybrid mapping. Sültmann H, et al. J Immunol, 2000 Dec 15. PMID 11120825
    3. Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model. Michailidou C, et al. Dis Model Mech, 2009 Jul-Aug. PMID 19470611
    4. Identification of vasculature-specific genes by microarray analysis of Etsrp/Etv2 overexpressing zebrafish embryos. Wong KS, et al. Dev Dyn, 2009 Jul. PMID 19504456
    5. Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Cannon JE, et al. Mech Dev, 2013 Feb. PMID 23072875, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ral guanine nucleotide dissociation stimulator-like 2
    Names
    ras-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115093.2 → NP_001108565.2  ral guanine nucleotide dissociation stimulator-like 2

      See identical proteins and their annotated locations for NP_001108565.2

      Status: PROVISIONAL

      Source sequence(s)
      BC162718
      UniProtKB/TrEMBL
      B3DHC8
      Related
      ENSDARP00000025191.7, ENSDART00000004052.8
      Conserved Domains (3) summary
      cd06224
      Location:89 → 168
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:234 → 497
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cl00155
      Location:604 → 688
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      45358955..45417216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158384.5 → XP_005158441.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

      See identical proteins and their annotated locations for XP_005158441.1

      UniProtKB/TrEMBL
      A0A8M2B5A7
      Conserved Domains (3) summary
      cd06224
      Location:111 → 190
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:256 → 519
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cl00155
      Location:626 → 710
      UBQ; Ubiquitin-like proteins

    2. XM_017351361.3 → XP_017206850.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5A7
      Conserved Domains (3) summary
      cd06224
      Location:111 → 190
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:256 → 519
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cl00155
      Location:626 → 710
      UBQ; Ubiquitin-like proteins

    3. XM_068214008.1 → XP_068070109.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5A7
    Nucleotide Protein Strain
    Heading Accession and Version

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