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    rasef2 RAS and EF-hand domain containing 2 [ Danio rerio (zebrafish) ]

    Gene ID: 572256, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rasef2provided by ZNC
    Official Full Name
    RAS and EF-hand domain containing 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070424-92
    See related
    Ensembl:ENSDARG00000074163 AllianceGenome:ZFIN:ZDB-GENE-070424-92
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rasef; zgc:162879
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in perinuclear region of cytoplasm. Is expressed in blastodisc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rasef2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (25754838..25771546, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (25768306..25785014, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene novel protein similar to elongation factor RNA polymerase II (ell) Neighboring gene FKBP prolyl isomerase 16 Neighboring gene small EDRK-rich factor 2a Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ba Neighboring gene zinc finger protein 710a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. m(6)A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition. Zhao BS, et al. Nature, 2017 Feb 23. PMID 28192787, Free PMC Article
    2. Ythdf m(6)A Readers Function Redundantly during Zebrafish Development. Kontur C, et al. Cell Rep, 2020 Dec 29. PMID 33378672, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC162879

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras and EF-hand domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089427.1 → NP_001082896.1  ras and EF-hand domain-containing protein

      See identical proteins and their annotated locations for NP_001082896.1

      Status: PROVISIONAL

      Source sequence(s)
      BC139657
      UniProtKB/Swiss-Prot
      A4QP53, A5WW21
      Related
      ENSDARP00000093820.3, ENSDART00000103046.4
      Conserved Domains (6) summary
      smart00175
      Location:468 → 634
      RAB; Rab subfamily of small GTPases
      cd00154
      Location:468 → 630
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      cd00051
      Location:5 → 60
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam07851
      Location:104 → 187
      TMPIT; TMPIT-like protein
      pfam13499
      Location:6 → 60
      EF-hand_7; EF-hand domain pair
      cl23720
      Location:180 → 290
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      25754838..25771546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A5WW21.1 GenPept UniProtKB/Swiss-Prot:A5WW21

    Gene LinkOut

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