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    ints11 integrator complex subunit 11 [ Danio rerio (zebrafish) ]

    Gene ID: 553648, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ints11provided by ZNC
    Official Full Name
    integrator complex subunit 11provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-13
    See related
    Ensembl:ENSDARG00000025212 AllianceGenome:ZFIN:ZDB-GENE-050522-13
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cpsf3l; zgc:110671
    Summary
    Predicted to enable RNA endonuclease activity. Acts upstream of or within regulation of RNA splicing. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities. Orthologous to human INTS11 (integrator complex subunit 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ints11 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (37062307..37085959, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (36959442..36983297, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3a Neighboring gene zmp:0000001084 Neighboring gene UBX domain protein 10 Neighboring gene ceramide-1-phosphate transfer protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Biallelic sequence variants in INTS1 in patients with developmental delays, cataracts, and craniofacial anomalies. Krall M, et al. Eur J Hum Genet, 2019 Apr. PMID 30622326, Free PMC Article
    2. The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling. Tao S, et al. Development, 2009 Aug. PMID 19605500
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110671

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity, producing 3'-phosphomonoesters IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 11
    Names
    CPSF3-like protein
    cleavage and polyadenylation specific factor 3-like
    cleavage and polyadenylation-specific factor 3-like protein
    int11
    NP_001018457.1
    XP_005166266.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020621.1 → NP_001018457.1  integrator complex subunit 11

      See identical proteins and their annotated locations for NP_001018457.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095364
      UniProtKB/Swiss-Prot
      Q503E1
      Related
      ENSDARP00000119202.1, ENSDART00000139662.3
      Conserved Domains (4) summary
      smart01027
      Location:245 → 363
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:4 → 442
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:377 → 416
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cd16291
      Location:6 → 204
      INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      37062307..37085959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166209.5 → XP_005166266.1  integrator complex subunit 11 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BDS7, F1QEY5
      Related
      ENSDARP00000032843.9, ENSDART00000031016.9
      Conserved Domains (4) summary
      smart01027
      Location:245 → 363
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:4 → 442
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:377 → 416
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cd16291
      Location:6 → 204
      INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q503E1.1 GenPept UniProtKB/Swiss-Prot:Q503E1

    Gene LinkOut

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