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    slc25a5 solute carrier family 25 member 5 [ Danio rerio (zebrafish) ]

    Gene ID: 192321, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc25a5provided by ZNC
    Official Full Name
    solute carrier family 25 member 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020419-9
    See related
    Ensembl:ENSDARG00000092553 AllianceGenome:ZFIN:ZDB-GENE-020419-9
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    CHUNP6931; sr:nyz040; wu:fe06b05; SI:bZ46J2.1; SI:bZ46J2.3; SI:bZ46J2.5; SI:bZ46J2.6; SI:bZ46J2.7; SI:bZ46J2.9; si:bz46j2.2
    Summary
    Predicted to enable ATP:ADP antiporter activity. Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to act upstream of or within mitochondrial ADP transmembrane transport and mitochondrial ATP transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in several structures, including bone element; eye; female organism; integument; and male organism. Orthologous to human SLC25A5 (solute carrier family 25 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See slc25a5 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (32881627..32884069, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (32541310..32543801, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:rp71-46j2.7 Neighboring gene ubiquitin-conjugating enzyme E2A (RAD6 homolog) Neighboring gene si:rp71-46j2.8 Neighboring gene solute carrier family 25 member 43 Neighboring gene ligand of numb-protein X 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Unsuccessful attempt at gene-editing by homologous recombination in the zebrafish germ line using the approach of "Rong and Golic". Brookfield R, et al. Transgenic Res, 2012 Oct. PMID 22434322, Free PMC Article
    2. Differentially sensitive neuronal subpopulations in the central nervous system and the formation of hindbrain heterotopias in ethanol-exposed zebrafish. Buckley DM, et al. Birth Defects Res, 2019 Jul 15. PMID 30793540, Free PMC Article
    3. Chronic unpredictable stress (CUS)-induced anxiety and related mood disorders in a zebrafish model: altered brain proteome profile implicates mitochondrial dysfunction. Chakravarty S, et al. PLoS One, 2013. PMID 23691016, Free PMC Article
    4. Identification of housekeeping genes suitable for gene expression analysis in the zebrafish. Casadei R, et al. Gene Expr Patterns, 2011 Mar-Apr. PMID 21281742
    5. Ethanol toxicity differs depending on the time of day. Vera LM, et al. PLoS One, 2018. PMID 29293684, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP:ADP antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrial ADP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitochondrial ATP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADP/ATP translocase 2
    Names
    solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
    solute carrier family 25 alpha, member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173247.1 → NP_775354.1  ADP/ATP translocase 2

      See identical proteins and their annotated locations for NP_775354.1

      Status: PROVISIONAL

      Source sequence(s)
      AF506216
      UniProtKB/TrEMBL
      A7MCM1, F6P6T8, Q8JHI0
      Related
      ENSDARP00000096504.3, ENSDART00000105726.4
      Conserved Domains (2) summary
      PTZ00169
      Location:7 → 298
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:6 → 101
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      32881627..32884069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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