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    cul1a cullin 1a [ Danio rerio (zebrafish) ]

    Gene ID: 323883, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cul1aprovided by ZNC
    Official Full Name
    cullin 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2603
    See related
    Ensembl:ENSDARG00000019239 AllianceGenome:ZFIN:ZDB-GENE-030131-2603
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Cul1; zgc:55747; zgc:77500; wu:fc13a10
    Summary
    Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within neutrophil chemotaxis and non-canonical NF-kappaB signal transduction. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human CUL1 (cullin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cul1a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (50229183..50272024, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (50494953..50537842, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene aryl-hydrocarbon receptor repressor b Neighboring gene uncharacterized LOC137488212 Neighboring gene MCM6 minichromosome maintenance deficient 6, like Neighboring gene contactin associated protein 2b Neighboring gene vimentin like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary diversification of MCM3 genes in Xenopus laevis and Danio rerio. Shinya M, et al. Cell Cycle, 2014. PMID 25485507, Free PMC Article
    2. MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation. Zhou W, et al. Cell Rep, 2018 Feb 13. PMID 29444433, Free PMC Article
    3. Zbtb46 Controls Dendritic Cell Activation by Reprogramming Epigenetic Regulation of cd80/86 and cd40 Costimulatory Signals in a Zebrafish Model. Shao T, et al. J Immunol, 2022 Jun 15. PMID 35675955
    4. Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Chen X, et al. Biomedicines, 2021 Nov 16. PMID 34829928, Free PMC Article
    5. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within non-canonical NF-kappaB signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cullin-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cullin-1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199659.2 → NP_955953.2  cullin-1a

      See identical proteins and their annotated locations for NP_955953.2

      Status: PROVISIONAL

      Source sequence(s)
      BC066480
      UniProtKB/TrEMBL
      A0A8M1PFM7, Q6NYS3
      Conserved Domains (2) summary
      smart00884
      Location:704 → 771
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:22 → 661
      Cullin; Cullin family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      50229183..50272024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478841.2 → XP_021334516.1  cullin-1a isoform X1

      UniProtKB/TrEMBL
      A0A8M1PFM7, Q6NYS3
      Related
      ENSDARP00000109683.2, ENSDART00000127623.4
      Conserved Domains (2) summary
      smart00884
      Location:704 → 771
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:22 → 661
      Cullin; Cullin family

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394515.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      326373..369093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395224.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      342134..381742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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