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    gbgt1l4 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4 [ Danio rerio (zebrafish) ]

    Gene ID: 387303, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gbgt1l4provided by ZNC
    Official Full Name
    globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031204-4
    See related
    Ensembl:ENSDARG00000068503 AllianceGenome:ZFIN:ZDB-GENE-031204-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb1003; zgc:66417
    Summary
    Predicted to enable glycosyltransferase activity. Predicted to be involved in lipid glycosylation. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and vesicle. Is expressed in several structures, including EVL; ectoderm; epidermis; pectoral fin musculature; and peripheral olfactory organ. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; graft-versus-host disease; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to several human genes including GBGT1 (globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gbgt1l4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (23788592..23805346, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (23284790..23301582, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495585 Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 8 Neighboring gene glycoprotein, alpha-galactosyltransferase 1 pseudogene Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Early developmental pathology due to cytochrome c oxidase deficiency is revealed by a new zebrafish model. Baden KN, et al. J Biol Chem, 2007 Nov 30. PMID 17761683
    2. Connexin 39.9 protein is necessary for coordinated activation of slow-twitch muscle and normal behavior in zebrafish. Hirata H, et al. J Biol Chem, 2012 Jan 6. PMID 22075003, Free PMC Article
    3. Long-term evolution of the CAZY glycosyltransferase 6 (ABO) gene family from fishes to mammals--a birth-and-death evolution model. Turcot-Dubois AL, et al. Glycobiology, 2007 May. PMID 17298992
    4. The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish. Huang G, et al. Autophagy, 2016 Aug 2. PMID 27171500, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4
    Names
    3-galctosyltransferase
    FS-L4
    alpha 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200125.1 → NP_956419.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4

      See identical proteins and their annotated locations for NP_956419.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055647
      UniProtKB/TrEMBL
      Q7SXD8
      Related
      ENSDARP00000089858.4, ENSDART00000099084.6
      Conserved Domains (1) summary
      cl11394
      Location:79 → 346
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      23788592..23805346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165128.5 → XP_005165185.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCB7
      Related
      ENSDARP00000120652.1, ENSDART00000133805.2
      Conserved Domains (1) summary
      cl11394
      Location:73 → 340
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. XM_005165129.5 → XP_005165186.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BCH3, A2CED5
      Related
      ENSDARP00000116300.1, ENSDART00000134184.3
      Conserved Domains (1) summary
      cl11394
      Location:72 → 339
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein
    Heading Accession and Version

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