ift172 intraflagellar transport 172 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ift172provided by ZNC
Official Full Name: intraflagellar transport 172provided by ZNC
Primary source: ZFIN:ZDB-GENE-040827-1
See related: Ensembl:ENSDARG00000041870 AllianceGenome:ZFIN:ZDB-GENE-040827-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Acts upstream of or within several processes, including photoreceptor cell maintenance; regulation of TOR signaling; and retina development in camera-type eye. Predicted to be located in cilium. Predicted to be part of intraciliary transport particle B. Predicted to be active in axoneme and ciliary basal body. Used to study cystic kidney disease and polycystic kidney disease. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 20; retinitis pigmentosa 71; and short-rib thoracic dysplasia 10 with or without polydactyly. Orthologous to human IFT172 (intraflagellar transport 172). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (38837238..38900415)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (38934359..38997536)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish IFT mutants also exhibited no dramatic changes in the craniofacial skeleton, somite formation, or motor neuron patterning.
Title: Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in intraciliary transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
part_of intraciliary transport particle B	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle B	ISS Inferred from Sequence or Structural Similarity more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: intraflagellar transport protein 172 homolog

Names: LIM-interacting protein; moe

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002312.1 → NP_001002312.1 intraflagellar transport protein 172 homolog

See identical proteins and their annotated locations for NP_001002312.1

Status: PROVISIONAL

Source sequence(s)

AY618923

UniProtKB/Swiss-Prot

Q5RHH4, Q6IVW1

UniProtKB/TrEMBL

B3DK94

Related

ENSDARP00000061333.2, ENSDART00000061334.4

Conserved Domains (5) summary

COG2319
Location:17 → 408

WD40; WD40 repeat [General function prediction only]

cd15832
Location:811 → 866

SNAP; TPR repeat [structural motif]

sd00039
Location:20 → 64

7WD40; WD40 repeat [structural motif]

cl02567
Location:17 → 318

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl24038
Location:808 → 997

SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family