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    mapk14b mitogen-activated protein kinase 14b [ Danio rerio (zebrafish) ]

    Gene ID: 266756, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mapk14bprovided by ZNC
    Official Full Name
    mitogen-activated protein kinase 14bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021007-1
    See related
    Ensembl:ENSDARG00000028721 AllianceGenome:ZFIN:ZDB-GENE-021007-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    p38b; zp38b; MAPK14
    Summary
    Predicted to enable MAP kinase activity. Predicted to be involved in several processes, including p38MAPK cascade; positive regulation of cell differentiation; and positive regulation of myoblast fusion. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mapk14b in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (2710525..2760373)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (2641137..2691019)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch211-160o17.6 Neighboring gene transmembrane protein 167B Neighboring gene SRSF protein kinase 1b Neighboring gene LHFPL tetraspan subfamily member 5a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cold-induced retrotransposition of fish LINEs. Chen S, et al. J Genet Genomics, 2017 Aug 20. PMID 28869113
    2. Sodium fluoride affects zebrafish behaviour and alters mRNA expressions of biomarker genes in the brain: Role of Nrf2/Keap1. Mukhopadhyay D, et al. Environ Toxicol Pharmacol, 2015 Sep. PMID 26245810
    3. Zebrafish as a Model to Unveil the Pro-Osteogenic Effects of Boron-Vitamin D3 Synergism. Sojan JM, et al. Front Nutr, 2022. PMID 35571926, Free PMC Article
    4. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Shi X, et al. Toxicol Sci, 2010 Jun. PMID 20200220
    5. Fishing the molecular bases of Treacher Collins syndrome. Weiner AM, et al. PLoS One, 2012. PMID 22295061, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to UV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in p38MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of myoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of myoblast fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of myotube differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 14B
    Names
    MAP kinase 14B
    MAP kinase p38b
    MAPK 14B
    mitogen-activated protein kinase p38b
    NP_001300688.1
    XP_017213684.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313759.1 → NP_001300688.1  mitogen-activated protein kinase 14B

      Status: VALIDATED

      Source sequence(s)
      BM037090, CR318593, EB900385, EH447521, EH457793
      UniProtKB/Swiss-Prot
      Q9DGE1
      UniProtKB/TrEMBL
      A0A8M1P824, F1RAA2
      Related
      ENSDARP00000040146.6, ENSDART00000040147.7
      Conserved Domains (2) summary
      smart00220
      Location:25 → 309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:7 → 351
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      2710525..2760373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358195.3 → XP_017213684.1  mitogen-activated protein kinase 14B isoform X1

      UniProtKB/Swiss-Prot
      Q9DGE1
      UniProtKB/TrEMBL
      A0A8M6Z107, F1QQ40
      Related
      ENSDARP00000035686.6, ENSDART00000030921.8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178223.2: Suppressed sequence

      Description
      NM_178223.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DGE1.1 GenPept UniProtKB/Swiss-Prot:Q9DGE1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.