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    p4ha2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 [ Danio rerio (zebrafish) ]

    Gene ID: 373132, updated on 4-Jan-2025

    Summary

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    Official Symbol
    p4ha2provided by ZNC
    Official Full Name
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030827-1
    See related
    Ensembl:ENSDARG00000010085 AllianceGenome:ZFIN:ZDB-GENE-030827-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:91948
    Summary
    Predicted to enable L-ascorbic acid binding activity; iron ion binding activity; and procollagen-proline 4-dioxygenase activity. Predicted to be located in endoplasmic reticulum lumen. Is expressed in several structures, including axis; heart rudiment; margin; notochord; and tail bud. Human ortholog(s) of this gene implicated in myopia. Orthologous to human P4HA2 (prolyl 4-hydroxylase subunit alpha 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See p4ha2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (43097860..43131752, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (43102684..43136893, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene janus kinase and microtubule interacting protein 2 Neighboring gene prolyl 4-hydroxylase subunit alpha-2 Neighboring gene heat shock protein 4a Neighboring gene zinc finger, CCHC domain containing 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function. Hyvärinen J, et al. J Biol Chem, 2010 Dec 31. PMID 20952382, Free PMC Article
    2. An expression pattern screen for genes involved in the induction of the posterior nervous system of zebrafish. Yoda H, et al. Differentiation, 2003 Mar. PMID 12641569
    3. Common responses of fish embryos to metals: an integrated analysis of transcriptomes and methylomes in zebrafish embryos under the stress of copper ions or silver nanoparticles. Tai Z, et al. Metallomics, 2019 Sep 1. PMID 31468037
    4. Coherent but overlapping expression of microRNAs and their targets during vertebrate development. Shkumatava A, et al. Genes Dev, 2009 Feb 15. PMID 19240133, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. transmembrane prolyl 4-hydroxylase in the zebrafish has a role in basement membrane and kidney function
      Title: Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prolyl 4-hydroxylase subunit alpha-2
    Names
    prolyl 4-hydroxylase A
    NP_001007286.1
    XP_005173949.1
    XP_005173950.1
    XP_005173951.1
    XP_009293964.1
    XP_068071911.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007285.1 → NP_001007286.1  prolyl 4-hydroxylase subunit alpha-2 precursor

      See identical proteins and their annotated locations for NP_001007286.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076508
      UniProtKB/TrEMBL
      A0A0R4IKZ3, A0A8M3ALV0, A0A8N7XJK4, B2GRW7, Q6DG45
      Related
      ENSDARP00000027028.6, ENSDART00000024137.8
      Conserved Domains (2) summary
      smart00702
      Location:347 → 498
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 154
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      43097860..43131752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173893.5 → XP_005173950.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

      UniProtKB/TrEMBL
      A0A286Y8C8, A0A8M2BLK0, A0A8M3ALV0
      Related
      ENSDARP00000143396.1, ENSDART00000174463.2
      Conserved Domains (2) summary
      smart00702
      Location:347 → 520
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 154
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. XM_005173894.5 → XP_005173951.1  prolyl 4-hydroxylase subunit alpha-2 isoform X4

      UniProtKB/TrEMBL
      A0A8M2BL71, A0A8M3ALV0
      Conserved Domains (2) summary
      smart00702
      Location:347 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 154
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_005173892.5 → XP_005173949.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BL82, A0A8M3ALV0
      Conserved Domains (2) summary
      smart00702
      Location:353 → 526
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 154
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    4. XM_009295689.4 → XP_009293964.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      UniProtKB/TrEMBL
      A0A8M3ALV0, A0A8M3AX68
      Conserved Domains (2) summary
      smart00702
      Location:353 → 524
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 154
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    5. XM_068215810.1 → XP_068071911.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

      UniProtKB/TrEMBL
      A0A8M3ALV0
    Nucleotide Protein Strain
    Heading Accession and Version

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