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    sema4ab sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab [ Danio rerio (zebrafish) ]

    Gene ID: 571290, updated on 9-Dec-2024

    Summary

    Official Symbol
    sema4abprovided by ZNC
    Official Full Name
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Abprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-363
    See related
    Ensembl:ENSDARG00000062352 AllianceGenome:ZFIN:ZDB-GENE-060503-363
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-78d16.2
    Summary
    Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Predicted to be involved in several processes, including axon guidance; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cone-rod dystrophy 10 and retinitis pigmentosa 35. Orthologous to human SEMA4A (semaphorin 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See sema4ab in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (24325504..24392032)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (24737618..24807775)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda-1 light chain Neighboring gene uncharacterized LOC101882070 Neighboring gene uncharacterized LOC137488519 Neighboring gene si:dkey-81h8.1 Neighboring gene thrombospondin 3b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General protein information

    Preferred Names
    semaphorin 4a; semaphorin-4A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      24325504..24392032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170096.5XP_005170153.1  semaphorin-4A isoform X1

      See identical proteins and their annotated locations for XP_005170153.1

      UniProtKB/TrEMBL
      A0A8M2BHW0
      Conserved Domains (3) summary
      cd11240
      Location:41484
      Sema_4; The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4)
      smart00423
      Location:485512
      PSI; domain found in Plexins, Semaphorins and Integrins
      cl11960
      Location:555631
      Ig; Immunoglobulin domain
    2. XM_694864.8XP_699956.4  semaphorin-4A isoform X2

      UniProtKB/TrEMBL
      A0A8N7UW38, F1R501
      Related
      ENSDARP00000084514.4, ENSDART00000090081.6
      Conserved Domains (3) summary
      cd11240
      Location:41484
      Sema_4; The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4)
      smart00423
      Location:485512
      PSI; domain found in Plexins, Semaphorins and Integrins
      cl11960
      Location:553626
      Ig; Immunoglobulin domain