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    brd1b bromodomain containing 1b [ Danio rerio (zebrafish) ]

    Gene ID: 100009661, updated on 9-Dec-2024

    Summary

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    Official Symbol
    brd1bprovided by ZNC
    Official Full Name
    bromodomain containing 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070209-98
    See related
    Ensembl:ENSDARG00000051798 AllianceGenome:ZFIN:ZDB-GENE-070209-98
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:158610
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human BRD1 (bromodomain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See brd1b in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (29688671..29712088)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (29245664..29269115)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB domain containing 13b Neighboring gene Pim-3 proto-oncogene, serine/threonine kinase Neighboring gene TAFA chemokine like family member 5b Neighboring gene proline rich 5 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. Brocal I, et al. BMC Genomics, 2016 Mar 24. PMID 27009152, Free PMC Article
    2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain-containing protein 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083030.1 → NP_001076499.1  bromodomain-containing protein 1b

      See identical proteins and their annotated locations for NP_001076499.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133132
      UniProtKB/TrEMBL
      A2RV14
      Related
      ENSDARP00000067969.4, ENSDART00000073478.6
      Conserved Domains (4) summary
      cd05512
      Location:559 → 656
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15677
      Location:211 → 264
      PHD_BRPF2; PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:45 → 193
      EPL1; Enhancer of polycomb-like
      cl22851
      Location:268 → 386
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      29688671..29712088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163142.5 → XP_005163199.1  bromodomain-containing protein 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BA66
      Conserved Domains (5) summary
      cd05512
      Location:559 → 656
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15677
      Location:211 → 264
      PHD_BRPF2; PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
      pfam10513
      Location:45 → 193
      EPL1; Enhancer of polycomb-like
      cl02554
      Location:1042 → 1157
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
      cl22851
      Location:268 → 386
      PHD_SF; PHD finger superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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