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    ndst2a N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2a [ Danio rerio (zebrafish) ]

    Gene ID: 793524, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ndst2aprovided by ZNC
    Official Full Name
    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060810-182
    See related
    Ensembl:ENSDARG00000086269 AllianceGenome:ZFIN:ZDB-GENE-060810-182
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7163473
    Summary
    Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in head and immature eye. Orthologous to human NDST2 (N-deacetylase and N-sulfotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ndst2a in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (21888204..22095717)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (21757746..21965269)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene si:ch211-51a6.2 Neighboring gene zinc finger, SWIM-type containing 8 Neighboring gene si:dkey-174i8.1 Neighboring gene calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Neuronal expression of ndst3 in early zebrafish development is responsive to Wnt signaling manipulation. Anderson RA, et al. Gene Expr Patterns, 2023 Mar. PMID 36503154, Free PMC Article
    2. The NDST gene family in zebrafish: role of NDST1B in pharyngeal arch formation. Filipek-Górniok B, et al. PLoS One, 2015. PMID 25767878, Free PMC Article
    3. An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. Fouchécourt S, et al. BMC Evol Biol, 2019 Jul 3. PMID 31269894, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
    XP_009305632.2
    XP_021328383.1
    XP_021328384.1
    XP_068069129.1
    XP_068069130.1
    XP_068074832.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      21888204..22095717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213029.1 → XP_068069130.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AZ54, F1QRK0

    2. XM_068213028.1 → XP_068069129.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AZ54, F1QRK0

    3. XM_009307357.4 → XP_009305632.2  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AZ54, F1QRK0
      Related
      ENSDARP00000149910.1, ENSDART00000182440.1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394882.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      71416..271806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068218731.1 → XP_068074832.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PU51

    2. XM_021472709.2 → XP_021328384.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PU51
      Conserved Domains (2) summary
      pfam00685
      Location:608 → 859
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:24 → 519
      HSNSD; heparan sulfate-N-deacetylase

    3. XM_021472708.2 → XP_021328383.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PU51
      Conserved Domains (2) summary
      pfam00685
      Location:608 → 859
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:24 → 519
      HSNSD; heparan sulfate-N-deacetylase
    Nucleotide Protein Strain
    Heading Accession and Version

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