U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    st14b ST14 transmembrane serine protease matriptase b [ Danio rerio (zebrafish) ]

    Gene ID: 777629, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    st14bprovided by ZNC
    Official Full Name
    ST14 transmembrane serine protease matriptase bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061103-613
    See related
    Ensembl:ENSDARG00000044655 AllianceGenome:ZFIN:ZDB-GENE-061103-613
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:152947
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within complement activation and proteolysis. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See st14b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (25275278..25295111, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (25239063..25258519, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 45B Neighboring gene guanine nucleotide binding protein (G protein), gamma 8 Neighboring gene nuclear factor related to kappaB binding protein Neighboring gene uncharacterized LOC137488866 Neighboring gene odorant receptor, family 92, subfamily A, member 1 Neighboring gene odorant receptor, family 92, subfamily A, member 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Morpholino knockdown of the ubiquitously expressed transmembrane serine protease TMPRSS4a in zebrafish embryos exhibits severe defects in organogenesis and cell adhesion. Ohler A, et al. Biol Chem, 2011 Jul. PMID 21657981
    2. Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Carney TJ, et al. Development, 2007 Oct. PMID 17728346
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within complement activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ST14 transmembrane serine protease matriptase b
    Names
    matriptase 1b
    suppression of tumorigenicity 14 (colon carcinoma) b
    suppression of tumorigenicity 14b
    NP_001071205.1
    XP_005161261.1
    XP_009293607.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077737.1 → NP_001071205.1  ST14 transmembrane serine protease matriptase b

      See identical proteins and their annotated locations for NP_001071205.1

      Status: PROVISIONAL

      Source sequence(s)
      BC125837
      UniProtKB/TrEMBL
      A0JMD7
      Related
      ENSDARP00000082343.4, ENSDART00000087910.6
      Conserved Domains (5) summary
      smart00020
      Location:513 → 747
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:233 → 346
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:425 → 459
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:514 → 750
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:92 → 180
      SEA; SEA domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      25275278..25295111 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009295332.4 → XP_009293607.1  ST14 transmembrane serine protease matriptase b isoform X1

      See identical proteins and their annotated locations for XP_009293607.1

      UniProtKB/TrEMBL
      A0A8M3AWU9, E9QD17
      Conserved Domains (5) summary
      smart00020
      Location:624 → 858
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:351 → 457
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:536 → 570
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:625 → 861
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:92 → 180
      SEA; SEA domain

    2. XM_005161204.5 → XP_005161261.1  ST14 transmembrane serine protease matriptase b isoform X1

      See identical proteins and their annotated locations for XP_005161261.1

      UniProtKB/TrEMBL
      A0A8M3AWU9, E9QD17
      Related
      ENSDARP00000119901.1, ENSDART00000147860.2
      Conserved Domains (5) summary
      smart00020
      Location:624 → 858
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:351 → 457
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:536 → 570
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:625 → 861
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:92 → 180
      SEA; SEA domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools