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    map3k7 mitogen-activated protein kinase kinase kinase 7 [ Danio rerio (zebrafish) ]

    Gene ID: 553788, updated on 9-Dec-2024

    Summary

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    Official Symbol
    map3k7provided by ZNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041001-135
    See related
    Ensembl:ENSDARG00000020469 AllianceGenome:ZFIN:ZDB-GENE-041001-135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    TAK1b; zgc:110612; si:ch211-225h9.1
    Summary
    Predicted to enable MAP kinase kinase kinase activity. Acts upstream of or within blood vessel morphogenesis. Predicted to be located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia; frontometaphyseal dysplasia 2; and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See map3k7 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (24151004..24183374, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (24251904..24284430, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene BTB and CNC homology 1, basic leucine zipper transcription factor 2b Neighboring gene uncharacterized LOC101886561 Neighboring gene transfer RNA proline (anticodon UGG) Neighboring gene transfer RNA serine (anticodon UGA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) activation requires phosphorylation of serine 412 by protein kinase A catalytic subunit α (PKACα) and X-linked protein kinase (PRKX). Ouyang C, et al. J Biol Chem, 2014 Aug 29. PMID 25028512, Free PMC Article
    2. The TGF beta activated kinase TAK1 regulates vascular development in vivo. Jadrich JL, et al. Development, 2006 Apr. PMID 16556914
    3. Identification of multipath genes differentially expressed in pathway-targeted microarrays in zebrafish infected and surviving spring viremia carp virus (SVCV) suggest preventive drug candidates. Encinas P, et al. PLoS One, 2013. PMID 24069208, Free PMC Article
    4. The spatial-temporal expression and functional divergence of bach homologs in zebrafish Danio rerio. Luo Q, et al. J Fish Biol, 2016 Apr. PMID 26992035
    5. Transforming growth factor-β1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis. Zhang CY, et al. Leukemia, 2018 Feb. PMID 28642593

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC110612

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within blood vessel morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 7
    Names
    TGF-beta-activated kinase TAK1
    tak1
    transforming growth factor beta-activated kinase 1b
    NP_001018586.2
    XP_009292938.1
    XP_009292939.1
    XP_068071544.1
    XP_068071545.1
    XP_068071546.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020750.2 → NP_001018586.2  mitogen-activated protein kinase kinase kinase 7

      Status: VALIDATED

      Source sequence(s)
      BX119992
      UniProtKB/TrEMBL
      Q503G7
      Related
      ENSDARP00000006286.8, ENSDART00000025862.11

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      24151004..24183374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215444.1 → XP_068071545.1  mitogen-activated protein kinase kinase kinase 7 isoform X3

      UniProtKB/TrEMBL
      Q503G7

    2. XM_009294664.4 → XP_009292939.1  mitogen-activated protein kinase kinase kinase 7 isoform X1

      See identical proteins and their annotated locations for XP_009292939.1

      UniProtKB/TrEMBL
      A0A0R4IVJ5, A0A8M3AT57, Q503G7
      Conserved Domains (2) summary
      smart00219
      Location:25 → 273
      TyrKc; Tyrosine kinase, catalytic domain
      cd14058
      Location:31 → 281
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1

    3. XM_009294663.4 → XP_009292938.1  mitogen-activated protein kinase kinase kinase 7 isoform X1

      See identical proteins and their annotated locations for XP_009292938.1

      UniProtKB/TrEMBL
      A0A0R4IVJ5, A0A8M3AT57, Q503G7
      Related
      ENSDARP00000138323.1, ENSDART00000171184.3
      Conserved Domains (2) summary
      smart00219
      Location:25 → 273
      TyrKc; Tyrosine kinase, catalytic domain
      cd14058
      Location:31 → 281
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1

    4. XM_068215445.1 → XP_068071546.1  mitogen-activated protein kinase kinase kinase 7 isoform X4

      UniProtKB/TrEMBL
      Q503G7

    5. XM_068215443.1 → XP_068071544.1  mitogen-activated protein kinase kinase kinase 7 isoform X2

      UniProtKB/TrEMBL
      Q503G7
    Nucleotide Protein Strain
    Heading Accession and Version

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