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    bin1b bridging integrator 1b [ Danio rerio (zebrafish) ]

    Gene ID: 447863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bin1bprovided by ZNC
    Official Full Name
    bridging integrator 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030425-1
    See related
    Ensembl:ENSDARG00000058820 AllianceGenome:ZFIN:ZDB-GENE-030425-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bin1; cb57; zgc:86701; im:7137547; si:ch211-114n24.7
    Summary
    Predicted to enable phospholipid binding activity and tau protein binding activity. Acts upstream of or within cardiac muscle contraction. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane and synaptic vesicle. Is expressed in adaxial cell; cardiovascular system; musculature system; and somite. Human ortholog(s) of this gene implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma. Orthologous to human BIN1 (bridging integrator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bin1b in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (6995294..7052603, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (6842320..6895434, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene si:ch211-114n24.6 Neighboring gene tubulin, alpha 8 like 4 Neighboring gene Indian hedgehog signaling molecule b Neighboring gene nonhomologous end-joining factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Bridging integrator 1 (Bin1) deficiency in zebrafish results in centronuclear myopathy. Smith LL, et al. Hum Mol Genet, 2014 Jul 1. PMID 24549043, Free PMC Article
    2. BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. Hong TT, et al. Heart Rhythm, 2012 May. PMID 22138472, Free PMC Article
    3. Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle. Lo HP, et al. J Cell Biol, 2021 Dec 6. PMID 34633413, Free PMC Article
    4. Dynamic Editome of Zebrafish under Aminoglycosides Treatment and Its Potential Involvement in Ototoxicity. Yan S, et al. Front Pharmacol, 2017. PMID 29213239, Free PMC Article
    5. In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish. Xiong Z, et al. Elife, 2021 Feb 16. PMID 33591275, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle.
      Title: Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tau protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myc box-dependent-interacting protein 1b
    Names
    bridging integrator 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004602.3 → NP_001004602.2  myc box-dependent-interacting protein 1b isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      CU655960, CU659670
      UniProtKB/TrEMBL
      A0A8M1N273, A0A8M9QFB8, F1QRX4
      Related
      ENSDARP00000076200.5, ENSDART00000081761.7

    2. NM_001327970.2 → NP_001314899.1  myc box-dependent-interacting protein 1b isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CU655960, CU659670
      UniProtKB/TrEMBL
      A0A2R8QMI5, A0A8M1P9C0
      Related
      ENSDARP00000155685.1, ENSDART00000181351.1
      Conserved Domains (2) summary
      cl12013
      Location:30 → 283
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:506 → 576
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      6995294..7052603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009302133.4 → XP_009300408.1  myc box-dependent-interacting protein 1b isoform X7

      UniProtKB/TrEMBL
      A0A8M3B348
      Conserved Domains (2) summary
      cl12013
      Location:30 → 240
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:463 → 533
      SH3; Src Homology 3 domain superfamily

    2. XM_068221704.1 → XP_068077805.1  myc box-dependent-interacting protein 1b isoform X4

    3. XM_009302130.4 → XP_009300405.1  myc box-dependent-interacting protein 1b isoform X3

      UniProtKB/TrEMBL
      A0A8M3AT25
      Conserved Domains (3) summary
      PHA03151
      Location:335 → 511
      PHA03151; hypothetical protein; Provisional
      cl12013
      Location:30 → 271
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:494 → 564
      SH3; Src Homology 3 domain superfamily

    4. XM_009302131.4 → XP_009300406.1  myc box-dependent-interacting protein 1b isoform X5

      UniProtKB/TrEMBL
      A0A8M3BA55
      Conserved Domains (2) summary
      cl12013
      Location:30 → 252
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:475 → 545
      SH3; Src Homology 3 domain superfamily

    5. XM_009302129.4 → XP_009300404.1  myc box-dependent-interacting protein 1b isoform X2

      UniProtKB/TrEMBL
      A0A8M3B064
      Conserved Domains (3) summary
      PHA03151
      Location:336 → 512
      PHA03151; hypothetical protein; Provisional
      cl12013
      Location:30 → 283
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:495 → 565
      SH3; Src Homology 3 domain superfamily

    6. XM_021476838.2 → XP_021332513.1  myc box-dependent-interacting protein 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M9PZM7
      Conserved Domains (3) summary
      cl12013
      Location:30 → 283
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:498 → 568
      SH3; Src Homology 3 domain superfamily
      cl26247
      Location:282 → 522
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    7. XM_009302132.4 → XP_009300407.1  myc box-dependent-interacting protein 1b isoform X6

      UniProtKB/TrEMBL
      A0A8M3AT31, A0A8M3B066
      Conserved Domains (2) summary
      cl12013
      Location:30 → 283
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:473 → 543
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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