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    map3k14a mitogen-activated protein kinase kinase kinase 14a [ Danio rerio (zebrafish) ]

    Gene ID: 100004261, updated on 9-Dec-2024

    Summary

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    Official Symbol
    map3k14aprovided by ZNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 14aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120215-80
    See related
    Ensembl:ENSDARG00000074060 AllianceGenome:ZFIN:ZDB-GENE-120215-80
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-260c8.4
    Summary
    Predicted to enable ATP binding activity and MAP kinase kinase kinase activity. Predicted to be involved in MAPK cascade and canonical NF-kappaB signal transduction. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MAP3K14 (mitogen-activated protein kinase kinase kinase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See map3k14a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (37707439..37742595)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (37565564..37600748)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene G patch domain containing 8 Neighboring gene uncharacterized LOC137490682 Neighboring gene uncharacterized LOC101885143 Neighboring gene si:dkey-260c8.6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish NIK Mediates IFN Induction by Regulating Activation of IRF3 and NF-κB. Chen B, et al. J Immunol, 2020 Apr 1. PMID 32066597
    2. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      37707439..37742595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002661208.7 → XP_002661254.1  mitogen-activated protein kinase kinase kinase 14

      See identical proteins and their annotated locations for XP_002661254.1

      UniProtKB/TrEMBL
      A0A8M1RLQ2, E7FEY1
      Related
      ENSDARP00000125811.1, ENSDART00000151236.3
      Conserved Domains (2) summary
      smart00220
      Location:278 → 520
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:272 → 533
      PKc_like; Protein Kinases, catalytic domain

    2. XM_068219258.1 → XP_068075359.1  mitogen-activated protein kinase kinase kinase 14

      UniProtKB/TrEMBL
      A0A8M1RLQ2, E7FEY1
    Nucleotide Protein Strain
    Heading Accession and Version

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