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    ice2 interactor of little elongator complex ELL subunit 2 [ Danio rerio (zebrafish) ]

    Gene ID: 100005372, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ice2provided by ZNC
    Official Full Name
    interactor of little elongator complex ELL subunit 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060306-1
    See related
    Ensembl:ENSDARG00000086670 AllianceGenome:ZFIN:ZDB-GENE-060306-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    narg2
    Summary
    Predicted to be involved in positive regulation of transcription by RNA polymerase III; snRNA transcription by RNA polymerase II; and snRNA transcription by RNA polymerase III. Predicted to be part of transcription elongation factor complex. Orthologous to human ICE2 (interactor of little elongation complex ELL subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See ice2 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (33972157..34008522)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (33486739..33523095)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene proepiregulin-like Neighboring gene RAR-related orphan receptor A, paralog a Neighboring gene annexin A2-A-like Neighboring gene annexin A2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Baraban SC, et al. Nat Commun, 2013. PMID 24002024, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of transcription elongation factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NMDA receptor-regulated protein 2; little elongation complex subunit 2
    Names
    NMDA receptor regulated 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      33972157..34008522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001344415.7 → XP_001344451.3  little elongation complex subunit 2

      UniProtKB/TrEMBL
      A0A8M1PZT2, E7EZF8
      Related
      ENSDARP00000104472.1, ENSDART00000121498.3
      Conserved Domains (1) summary
      pfam10505
      Location:657 → 853
      NARG2_C; NMDA receptor-regulated gene protein 2 C-terminus

    RNA

    1. XR_011008800.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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