U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    fyco1a FYVE and coiled-coil domain autophagy adaptor 1a [ Danio rerio (zebrafish) ]

    Gene ID: 565649, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    fyco1aprovided by ZNC
    Official Full Name
    FYVE and coiled-coil domain autophagy adaptor 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-110411-276
    See related
    Ensembl:ENSDARG00000104500 AllianceGenome:ZFIN:ZDB-GENE-110411-276
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch73-217b7.5
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in plus-end-directed vesicle transport along microtubule and positive regulation of autophagosome maturation. Predicted to be active in autophagosome; late endosome; and lysosome. Human ortholog(s) of this gene implicated in cataract 18. Orthologous to human FYCO1 (FYVE and coiled-coil domain autophagy adaptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See fyco1a in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (39963936..40045469)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (40071013..40151304)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene chemokine XC receptor 1-like Neighboring gene chemokine (C motif) receptor 1a, duplicate 1 Neighboring gene FYVE and coiled-coil domain-containing protein 1-like Neighboring gene growth hormone releasing hormone receptor, like Neighboring gene G protein signaling modulator 2, like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    2. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in plus-end-directed vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    FYVE and coiled-coil domain-containing protein 1
    Names
    FYVE and coiled-coil domain containing 1a

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      39963936..40045469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216950.1 → XP_068073051.1  FYVE and coiled-coil domain-containing protein 1

      UniProtKB/TrEMBL
      A0A0R4IIH4, A0A8M3B6E4

    2. XM_009297090.4 → XP_009295365.1  FYVE and coiled-coil domain-containing protein 1

      See identical proteins and their annotated locations for XP_009295365.1

      UniProtKB/TrEMBL
      A0A0R4IIH4, A0A8M3B6E4
      Related
      ENSDARP00000134006.1, ENSDART00000166539.2
      Conserved Domains (5) summary
      cd15726
      Location:1191 → 1247
      FYVE_FYCO1; FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
      pfam10174
      Location:322 → 1139
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam13897
      Location:1438 → 1482
      GOLD_2; Golgi-dynamics membrane-trafficking
      cl02689
      Location:51 → 165
      RUN; RUN domain
      cl19548
      Location:383 → 583
      DUF515; Protein of unknown function (DUF515)

    3. XM_009297091.4 → XP_009295366.1  FYVE and coiled-coil domain-containing protein 1

      See identical proteins and their annotated locations for XP_009295366.1

      UniProtKB/TrEMBL
      A0A0R4IIH4, A0A8M3B6E4
      Conserved Domains (5) summary
      cd15726
      Location:1191 → 1247
      FYVE_FYCO1; FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
      pfam10174
      Location:322 → 1139
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam13897
      Location:1438 → 1482
      GOLD_2; Golgi-dynamics membrane-trafficking
      cl02689
      Location:51 → 165
      RUN; RUN domain
      cl19548
      Location:383 → 583
      DUF515; Protein of unknown function (DUF515)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools