rab11a RAB11a, member RAS oncogene family [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rab11aprovided by ZNC
Official Full Name: RAB11a, member RAS oncogene familyprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041114-53
See related: Ensembl:ENSDARG00000041450 AllianceGenome:ZFIN:ZDB-GENE-041114-53
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fi15h09; zgc:103679
Summary: Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within Kupffer's vesicle development; angiogenesis; and melanosome transport. Located in recycling endosome. Is expressed in several structures, including brain; caudal vein plexus; digestive system; epidermal cell; and lens epithelium. Orthologous to human RAB11A (RAB11A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (19131787..19137823)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (19142721..19148757)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during zebrafish left-right organizer development.
Title: Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during zebrafish left-right organizer development.
Coordinated assembly and release of adhesions builds apical junctional belts during de novo polarisation of an epithelial tube.
Title: Coordinated assembly and release of adhesions builds apical junctional belts during de novo polarisation of an epithelial tube.
Results found all three rab11 genes (rab11a, rab11ba and rab11bb) are highly conserved especially for their GTPase domains, and highly enriched in the central nervous system, but in different areas of the brain. rab11a was also expressed in caudal vein, pronephric duct, proctodeum, pharyngeal arches and digestive duct. rab11a and rab11ba have maternal expressions in embryos.
Title: Expression analysis of Rab11 during zebrafish embryonic development.
Pard3 and Rab11a are necessary for lumen formation in the neural rod.
Title: Mirror-symmetric microtubule assembly and cell interactions drive lumen formation in the zebrafish neural rod.
The established transgenic lines ubiquitously express EGFP fusions of Rab5c (early endosomes), Rab11a (recycling endosomes), and Rab7 (late endosomes) to study localization and dynamics during development.
Title: Generation of Rab-based transgenic lines for in vivo studies of endosome biology in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Kupffer's vesicle development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanosome transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in transport vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-11A

NP_001007360.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.