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    plcd1b phospholipase C, delta 1b [ Danio rerio (zebrafish) ]

    Gene ID: 337489, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plcd1bprovided by ZNC
    Official Full Name
    phospholipase C, delta 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9435
    See related
    Ensembl:ENSDARG00000034080 AllianceGenome:ZFIN:ZDB-GENE-030131-9435
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Plcd1; fj78d10; zgc:55868; wu:fj78d10
    Summary
    Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Predicted to act upstream of or within intracellular signal transduction and lipid catabolic process. Predicted to be active in cytoplasm. Is expressed in lens; neuromast; and solid lens vesicle. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (phospholipase C delta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See plcd1b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (21387898..21438555, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (21729836..21780430, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene hedgehog acyltransferase like, a Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like b Neighboring gene microRNA 26a-2 Neighboring gene uncharacterized LOC108179685 Neighboring gene AFG3-like AAA ATPase 2 Neighboring gene inhibin subunit beta Ab

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Duplication of phospholipase C-delta gene family in fish genomes. Kim MS, et al. Genomics, 2008 Nov. PMID 18722520
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b
    Names
    DrPLC-delta 1B
    NP_956362.1
    XP_005163413.1
    XP_068079275.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200068.1 → NP_956362.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b

      See identical proteins and their annotated locations for NP_956362.1

      Status: PROVISIONAL

      Source sequence(s)
      BC051157
      UniProtKB/TrEMBL
      Q7ZU40
      Related
      ENSDARP00000046097.6, ENSDART00000046098.9
      Conserved Domains (7) summary
      cd00275
      Location:620 → 745
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08629
      Location:291 → 587
      PI-PLCc_delta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta1
      PLN02228
      Location:209 → 741
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:21 → 136
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam00169
      Location:25 → 127
      PH; PH domain
      pfam09279
      Location:210 → 291
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam14788
      Location:156 → 205
      EF-hand_10; EF hand

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      21387898..21438555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223174.1 → XP_068079275.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b isoform X2

    2. XM_005163356.5 → XP_005163413.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BAJ8
      Conserved Domains (7) summary
      cd00275
      Location:643 → 768
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08629
      Location:314 → 610
      PI-PLCc_delta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta1
      PLN02228
      Location:232 → 764
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:44 → 159
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam00169
      Location:48 → 150
      PH; PH domain
      pfam09279
      Location:233 → 314
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam14788
      Location:179 → 228
      EF-hand_10; EF hand
    Nucleotide Protein Strain
    Heading Accession and Version

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