hspb1 heat shock protein, alpha-crystallin-related, 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hspb1provided by ZNC
Official Full Name: heat shock protein, alpha-crystallin-related, 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030326-4
See related: Ensembl:ENSDARG00000041065 AllianceGenome:ZFIN:ZDB-GENE-030326-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hsp1; cb153; cb660; hsp25; hsp27; sb:cb660; id:ibd2821; zgc:103437
Summary: Predicted to enable unfolded protein binding activity. Acts upstream of or within regulation of myofibril size; response to arsenic-containing substance; and response to heat. Located in cytoplasm and nucleus. Is expressed in several structures, including mesoderm; musculature system; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; autosomal dominant distal hereditary motor neuronopathy 3; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (3568125..3574199, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (3238393..3244467, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of HspB1 specifically reduces myofibril size in embryonic craniofacial muscles.
Title: Small heat shock protein HSPB1 regulates growth of embryonic zebrafish craniofacial muscles.
Hsp27 is dispensable for zebrafish morphogenesis but could play a role in long-term maintenance of heart and muscle tissues.
Title: Hsp27 is persistently expressed in zebrafish skeletal and cardiac muscle tissues but dispensable for their morphogenesis.
The data support a mechanism of Hsp27 function where interactions with the titin filament system protect myofibrils from stress-induced degradation.
Title: Hsp27 associates with the titin filament system in heat-shocked zebrafish cardiomyocytes.
hspb1 is expressed during development
Title: Genome-wide analysis and expression profiling of the small heat shock proteins in zebrafish.
Results show the sequence, expression, regulation, and function of a zebrafish protein (zfHsp27) and define zebrafish as a new model for the study of Hsp27 function.
Title: Cloning, characterization, and heat stress-induced redistribution of a protein homologous to human hsp27 in the zebrafish Danio rerio.
initial upregulation of hsp27 expression occurs during early gastrulation
Title: Developmentally regulated gene expression of the small heat shock protein Hsp27 in zebrafish embryos.

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General gene information

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Markers

fe47d01.x1 (e-PCR)
- UniSTS:196480

fe50e01.y1 (e-PCR)
- UniSTS:196582

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of myofibril size	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to arsenic-containing substance	IDA Inferred from Direct Assay more info	PubMed
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to heat	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
NOT located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heat shock protein beta-1

Names: 25 kDa heat shock protein; heat shock 27kDa protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008615.2 → NP_001008615.2 heat shock protein beta-1

See identical proteins and their annotated locations for NP_001008615.2

Status: VALIDATED

Source sequence(s)

EH441740, EH459900

UniProtKB/TrEMBL

A0A8M1N3D0, A4VAK4

Related

ENSDARP00000060161.4, ENSDART00000060162.5

Conserved Domains (2) summary

cd06475
Location:91 → 176

ACD_HspB1_like; Alpha crystallin domain (ACD) found in mammalian small (s)heat shock protein (Hsp)-27 (also denoted HspB1 in human) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally ...

COG0071
Location:94 → 191

IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]