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    cltcb clathrin, heavy chain b (Hc) [ Danio rerio (zebrafish) ]

    Gene ID: 503600, updated on 4-Jan-2025

    Summary

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    Official Symbol
    cltcbprovided by ZNC
    Official Full Name
    clathrin, heavy chain b (Hc)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050227-12
    See related
    Ensembl:ENSDARG00000090716 AllianceGenome:ZFIN:ZDB-GENE-050227-12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd07f11; im:7145213; wu:fd07f11; zgc:113234
    Summary
    Predicted to enable clathrin light chain binding activity and structural molecule activity. Predicted to be involved in intracellular protein transport. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in clathrin-coated pit and cytoplasmic vesicle. Predicted to be part of clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; and clathrin complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See cltcb in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (17285989..17340198)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (17349958..17404176)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101884208 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 40 Neighboring gene vacuole membrane protein 1 Neighboring gene microRNA 21-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease. Dong X, et al. Nat Neurosci, 2018 Oct. PMID 30224808, Free PMC Article
    2. auts2 Features and Expression Are Highly Conserved during Evolution Despite Different Evolutionary Fates Following Whole Genome Duplication. Merdrignac C, et al. Cells, 2022 Aug 30. PMID 36078102, Free PMC Article
    3. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables clathrin light chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin coat of coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin coat of trans-Golgi network vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    clathrin heavy chain 1
    Names
    clathrin, heavy polypeptide b (Hc)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001194978.1 → NP_001181907.1  clathrin heavy chain 1

      Status: PROVISIONAL

      Source sequence(s)
      CR848791
      UniProtKB/TrEMBL
      A0A8M1NX73, A0A8M2B4A2, E9QBV1
      Related
      ENSDARP00000119038.1, ENSDART00000134512.3
      Conserved Domains (6) summary
      smart00299
      Location:1274 → 1416
      CLH; Clathrin heavy chain repeat homology
      sd00006
      Location:1104 → 1131
      TPR; TPR repeat [structural motif]
      pfam00637
      Location:983 → 1119
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:198 → 234
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:331 → 353
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:364 → 421
      Clathrin_H_link; Clathrin-H-link

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      17285989..17340198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157424.3 → XP_005157481.1  clathrin heavy chain 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3J4, A0A8M2B3R2
      Conserved Domains (6) summary
      smart00299
      Location:1274 → 1416
      CLH; Clathrin heavy chain repeat homology
      sd00006
      Location:1104 → 1131
      TPR; TPR repeat [structural motif]
      pfam00637
      Location:983 → 1119
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:198 → 234
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:331 → 353
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:364 → 421
      Clathrin_H_link; Clathrin-H-link
    Nucleotide Protein Strain
    Heading Accession and Version

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