rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rfngprovided by ZNC
Official Full Name: RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5418
See related: Ensembl:ENSDARG00000019746 AllianceGenome:ZFIN:ZDB-GENE-030131-5418
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rfg; fd16f05; wu:fd16f05; zgc:136694
Summary: Predicted to enable O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within brain segmentation; fourth ventricle development; and rhombomere boundary formation. Predicted to be located in Golgi membrane. Is expressed in hindbrain. Orthologous to human RFNG (RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (3058989..3077395, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (3024256..3042662, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rac3b, rfng, and sgca genes are all part of the same interaction domain, with most of the chromatin interactions occurring within a region of 170kb. The novel rac3b/rfng/sgca regulatory cluster, which is specifically expressed at the boundaries, emerged in the Ostariophysi superorder by chromosomal rearrangement that generated new cis-regulatory interactions.
Title: Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation.
The sequence and embryonic expression of rfng were studied.
Title: Sequence and embryonic expression of three zebrafish fringe genes: lunatic fringe, radical fringe, and manic fringe.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fourth ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pattern specification process	IEA Inferred from Electronic Annotation more info
involved_in regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within rhombomere boundary formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-1,3-N-acetylglucosaminyltransferase radical fringe

Names: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; radical fringe homolog

NP_001001830.2

EC 2.4.1.222

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001830.2 → NP_001001830.2 beta-1,3-N-acetylglucosaminyltransferase radical fringe

Status: VALIDATED

Source sequence(s)

BX548040

UniProtKB/Swiss-Prot

Q6KFX9

UniProtKB/TrEMBL

A0A8M1MZN7, F1QXC7

Related

ENSDARP00000105906.2, ENSDART00000126315.3

Conserved Domains (1) summary

pfam02434
Location:92 → 341

Fringe; Fringe-like