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    ncoa2 nuclear receptor coactivator 2 [ Danio rerio (zebrafish) ]

    Gene ID: 81884, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncoa2provided by ZNC
    Official Full Name
    nuclear receptor coactivator 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010406-3
    See related
    Ensembl:ENSDARG00000017929 AllianceGenome:ZFIN:ZDB-GENE-010406-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tif2; wu:fc41a10; wu:fe26a11
    Summary
    Enables nuclear thyroid hormone receptor binding activity. Involved in granulocyte differentiation and primitive hemopoiesis. Acts upstream of or within chordate embryonic development. Predicted to be active in nucleus. Is expressed in several structures, including eye; gill; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; lung non-small cell carcinoma; and prostate adenocarcinoma. Orthologous to human NCOA2 (nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ncoa2 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (14237944..14444945)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (14093413..14300526)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene XK, Kell blood group complex subunit-related family, member 9 Neighboring gene translocation associated membrane protein 1 Neighboring gene uncharacterized LOC137489222 Neighboring gene PR domain containing 14 Neighboring gene putative nuclease HARBI1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning, genomic organization, and expression analysis of zebrafish nuclear receptor coactivator, TIF2. Tan JH, et al. Zebrafish, 2005. PMID 18248177
    2. An F-domain introduced by alternative splicing regulates activity of the zebrafish thyroid hormone receptor alpha. Takayama S, et al. Gen Comp Endocrinol, 2008 Jan 1. PMID 17583703, Free PMC Article
    3. Co-option of the PRDM14-CBFA2T complex from motor neurons to pluripotent cells during vertebrate evolution. Kawaguchi M, et al. Development, 2019 Jan 28. PMID 30630825
    4. A role for the transcription intermediary factor 2 in zebrafish myelopoiesis. Zhuravleva J, et al. Exp Hematol, 2008 May. PMID 18295965
    5. Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish. McGrail M, et al. PLoS One, 2011 Apr 21. PMID 21533036, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables nuclear receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nuclear thyroid hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in granulocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within primitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in primitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor coactivator 2
    Names
    grip1
    src2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131777.1 → NP_571852.1  nuclear receptor coactivator 2

      See identical proteins and their annotated locations for NP_571852.1

      Status: PROVISIONAL

      Source sequence(s)
      AF323989
      UniProtKB/Swiss-Prot
      B3DK53, Q98TW1
      Related
      ENSDARP00000107210.2, ENSDART00000124740.4
      Conserved Domains (8) summary
      smart00353
      Location:36 → 89
      HLH; helix loop helix domain
      smart00091
      Location:119 → 176
      PAS; PAS domain
      pfam07469
      Location:1354 → 1410
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1061 → 1106
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:629 → 705
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:267 → 375
      PAS_11; PAS domain
      pfam16279
      Location:728 → 803
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:460 → 567
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      14237944..14444945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009297336.4 → XP_009295611.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AP61, E7F5J8
      Related
      ENSDARP00000157542.1, ENSDART00000182279.1
      Conserved Domains (8) summary
      smart00353
      Location:36 → 89
      HLH; helix loop helix domain
      smart00091
      Location:119 → 176
      PAS; PAS domain
      pfam07469
      Location:1354 → 1410
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1061 → 1106
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:629 → 705
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:267 → 375
      PAS_11; PAS domain
      pfam16279
      Location:728 → 803
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:460 → 567
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    2. XM_021470228.2 → XP_021325903.1  nuclear receptor coactivator 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PG56
      Conserved Domains (9) summary
      smart00353
      Location:36 → 89
      HLH; helix loop helix domain
      smart00091
      Location:119 → 176
      PAS; PAS domain
      pfam07469
      Location:1354 → 1410
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1061 → 1106
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:629 → 705
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:880 → 1218
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:267 → 375
      PAS_11; PAS domain
      pfam16279
      Location:728 → 803
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:460 → 558
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    3. XM_009297338.4 → XP_009295613.1  nuclear receptor coactivator 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AZ20, F6NH98
      Related
      ENSDARP00000109306.2, ENSDART00000124181.4
      Conserved Domains (8) summary
      smart00353
      Location:36 → 89
      HLH; helix loop helix domain
      smart00091
      Location:119 → 176
      PAS; PAS domain
      pfam07469
      Location:1289 → 1340
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1061 → 1106
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:629 → 705
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:267 → 375
      PAS_11; PAS domain
      pfam16279
      Location:728 → 803
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:460 → 567
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    4. XM_068217125.1 → XP_068073226.1  nuclear receptor coactivator 2 isoform X4

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395168.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      250028..353232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q98TW1.1 GenPept UniProtKB/Swiss-Prot:Q98TW1

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