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    naa50 N-alpha-acetyltransferase 50, NatE catalytic subunit [ Danio rerio (zebrafish) ]

    Gene ID: 445229, updated on 4-Jan-2025

    Summary

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    Official Symbol
    naa50provided by ZNC
    Official Full Name
    N-alpha-acetyltransferase 50, NatE catalytic subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-142
    See related
    Ensembl:ENSDARG00000027825 AllianceGenome:ZFIN:ZDB-GENE-040801-142
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mak3; nat13; wu:fb01d06; wu:fe47h02; zgc:100949
    Summary
    Predicted to enable histone H4 acetyltransferase activity and peptide alpha-N-acetyltransferase activity. Acts upstream of or within somitogenesis. Predicted to be located in cytosol and nucleus. Predicted to be part of NatA complex. Is expressed in blood vasculature; head; and myotome. Orthologous to human NAA50 (N-alpha-acetyltransferase 50, NatE catalytic subunit). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See naa50 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (21174889..21183616)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (21030422..21039197)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene GRAM domain containing 1c Neighboring gene uncharacterized LOC137489236 Neighboring gene ATPase H+ transporting V1 subunit Ab Neighboring gene upstream transcription factor family member 3 Neighboring gene BOC cell adhesion associated, oncogene regulated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The N-terminal acetyltransferase Naa10 is essential for zebrafish development. Ree R, et al. Biosci Rep, 2015 Aug 6. PMID 26251455, Free PMC Article
    2. Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. Wenzlau JM, et al. Circ Res, 2006 Mar 31. PMID 16484612
    3. Identification of differentially expressed genes between cloned and zygote-developing zebrafish (Danio rerio) embryos at the dome stage using suppression subtractive hybridization. Luo D, et al. Biol Reprod, 2009 Apr. PMID 19092113
    4. Expression screening and annotation of a zebrafish myoblast cDNA library. Baxendale S, et al. Gene Expr Patterns, 2009 Feb. PMID 19007914
    5. Genetic landscape of T cells identifies synthetic lethality for T-ALL. O'Meara CP, et al. Commun Biol, 2021 Oct 20. PMID 34671088, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in establishment of mitotic sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid cohesion, centromeric ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 50
    Names
    MAK31-like protein
    Mak3 homolog
    N-acetyltransferase 13
    N-acetyltransferase NAT13
    N-epsilon-acetyltransferase 50
    natE catalytic subunit
    NP_001003623.1
    XP_005162748.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003623.1 → NP_001003623.1  N-alpha-acetyltransferase 50

      See identical proteins and their annotated locations for NP_001003623.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078316
      UniProtKB/Swiss-Prot
      Q6DBY2
      Related
      ENSDARP00000128410.1, ENSDART00000154940.3
      Conserved Domains (1) summary
      COG0456
      Location:9 → 144
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      21174889..21183616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162691.5 → XP_005162748.1  N-alpha-acetyltransferase 50 isoform X1

      See identical proteins and their annotated locations for XP_005162748.1

      UniProtKB/TrEMBL
      A0A8M2B9S1, X1WEV8
      Related
      ENSDARP00000128760.1, ENSDART00000155977.3
      Conserved Domains (1) summary
      COG0456
      Location:10 → 145
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395170.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      192246..200968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DBY2.1 GenPept UniProtKB/Swiss-Prot:Q6DBY2

    Gene LinkOut

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