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    snx27b sorting nexin 27b [ Danio rerio (zebrafish) ]

    Gene ID: 393512, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snx27bprovided by ZNC
    Official Full Name
    sorting nexin 27bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1529
    See related
    Ensembl:ENSDARG00000016977 AllianceGenome:ZFIN:ZDB-GENE-040426-1529
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    snx27; zgc:66094; zgc:77922
    Summary
    Predicted to enable phosphatidylinositol binding activity. Acts upstream of or within axonogenesis. Predicted to be located in membrane. Predicted to be active in early endosome. Orthologous to human SNX27 (sorting nexin 27). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See snx27b in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (23495608..23525405)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (23580534..23610700)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene ictacalcin Neighboring gene ictacalcin 2 Neighboring gene adenosine deaminase RNA specific Neighboring gene uncharacterized LOC101885210

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. SNX27-FERM-SNX1 complex structure rationalizes divergent trafficking pathways by SNX17 and SNX27. Yong X, et al. Proc Natl Acad Sci U S A, 2021 Sep 7. PMID 34462354, Free PMC Article
    2. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Xu L, et al. Hepatology, 2012 Jun. PMID 22213104
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC66094

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-27b
    Names
    sorting nexin family member 27
    sorting nexin family member 27b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200540.1 → NP_956834.1  sorting nexin-27b

      See identical proteins and their annotated locations for NP_956834.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056315
      UniProtKB/TrEMBL
      Q6P3G2, Q6PHV2
      Related
      ENSDARP00000011221.8, ENSDART00000021092.9
      Conserved Domains (4) summary
      cd06886
      Location:165 → 270
      PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27
      cd01777
      Location:279 → 365
      SNX27_RA; Ubiquitin domain of SNX27 (sorting nexin protein 27)
      cd00992
      Location:46 → 138
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13338
      Location:430 → 531
      FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      23495608..23525405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158092.5 → XP_005158149.1  sorting nexin-27b isoform X1

      UniProtKB/TrEMBL
      A0A8M2B4E4
      Conserved Domains (4) summary
      cd06886
      Location:165 → 270
      PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27
      cd01777
      Location:279 → 365
      SNX27_RA; Ubiquitin domain of SNX27 (sorting nexin protein 27)
      cd00992
      Location:46 → 138
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13338
      Location:430 → 531
      FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27
    Nucleotide Protein Strain
    Heading Accession and Version

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