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    vdac3 voltage-dependent anion channel 3 [ Danio rerio (zebrafish) ]

    Gene ID: 406529, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vdac3provided by ZNC
    Official Full Name
    voltage-dependent anion channel 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2380
    See related
    Ensembl:ENSDARG00000003695 AllianceGenome:ZFIN:ZDB-GENE-040426-2380
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77898; wu:fb01e12
    Summary
    Predicted to enable voltage-gated monoatomic anion channel activity. Acts upstream of or within fin regeneration. Predicted to be located in membrane and mitochondrion. Predicted to be part of pore complex. Predicted to be active in mitochondrial outer membrane. Is expressed in adaxial cell; musculature system; nervous system; somite; and trigeminal placode. Orthologous to human VDAC3 (voltage dependent anion channel 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See vdac3 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (2412583..2434272, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (2354040..2375748, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene plasminogen activator, tissue Neighboring gene inhibitor of nuclear factor kappa B kinase subunit beta Neighboring gene enkurin domain containing 1 Neighboring gene polymerase (DNA directed), beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Glutamate 73 Promotes Anti-arrhythmic Effects of Voltage-Dependent Anion Channel Through Regulation of Mitochondrial Ca(2+) Uptake. Shimizu H, et al. Front Physiol, 2021. PMID 34483974, Free PMC Article
    2. Chronic unpredictable stress (CUS)-induced anxiety and related mood disorders in a zebrafish model: altered brain proteome profile implicates mitochondrial dysfunction. Chakravarty S, et al. PLoS One, 2013. PMID 23691016, Free PMC Article
    3. Proteomic analysis of zebrafish caudal fin regeneration. Saxena S, et al. Mol Cell Proteomics, 2012 Jun. PMID 22278371, Free PMC Article
    4. Characterization of Biological Pathways Regulating Acute Cold Resistance of Zebrafish. Ren J, et al. Int J Mol Sci, 2021 Mar 16. PMID 33809683, Free PMC Article
    5. Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish. Faria M, et al. Sci Rep, 2019 Nov 11. PMID 31712630, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated monoatomic anion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fin regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    voltage-dependent anion-selective channel protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213246.1 → NP_998411.1  voltage-dependent anion-selective channel protein 3

      See identical proteins and their annotated locations for NP_998411.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065468
      UniProtKB/TrEMBL
      A0A8M2BER1, Q6P0S2
      Related
      ENSDARP00000121437.1, ENSDART00000134044.3
      Conserved Domains (1) summary
      cd07306
      Location:4 → 282
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      2412583..2434272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166746.4 → XP_005166803.1  voltage-dependent anion-selective channel protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BEA1, A0A8M2BER1
      Related
      ENSDARP00000123532.1, ENSDART00000137262.2
      Conserved Domains (1) summary
      cd07306
      Location:29 → 307
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
    Nucleotide Protein Strain
    Heading Accession and Version

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