mcm6l MCM6 minichromosome maintenance deficient 6, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mcm6lprovided by ZNC
Official Full Name: MCM6 minichromosome maintenance deficient 6, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050913-141
See related: Ensembl:ENSDARG00000033231 AllianceGenome:ZFIN:ZDB-GENE-050913-141
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Mcm6; MCM6m; zgc:112244
Summary: Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded 3'-5' DNA helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; and mitotic DNA replication. Predicted to act upstream of or within DNA duplex unwinding and DNA replication. Predicted to be part of MCM complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (50199738..50225513, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (50465508..50491283, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi88d09.y1 (e-PCR)
- UniSTS:198157

fi56b10.x1 (e-PCR)
- UniSTS:197711

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
contributes_to single-stranded 3'-5' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication initiation	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IEA Inferred from Electronic Annotation more info
involved_in DNA unwinding involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via break-induced replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic DNA replication	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MCM complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MCM complex	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: MCM6 minichromosome maintenance deficient 6, like

Names: maternal Mcm6 protein

NP_001020704.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025533.1 → NP_001020704.1 MCM6 minichromosome maintenance deficient 6, like

See identical proteins and their annotated locations for NP_001020704.1

Status: PROVISIONAL

Source sequence(s)

BC096872

UniProtKB/TrEMBL

Q4V9J1

Related

ENSDARP00000000042.9, ENSDART00000000042.11

Conserved Domains (3) summary

smart00350
Location:116 → 651

MCM; minichromosome maintenance proteins

pfam14551
Location:23 → 133

MCM_N; MCM N-terminal domain

cl21455
Location:441 → 528

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases