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    sox19b SRY-box transcription factor 19b [ Danio rerio (zebrafish) ]

    Gene ID: 64812, updated on 15-Dec-2024

    Summary

    Official Symbol
    sox19bprovided by ZNC
    Official Full Name
    SRY-box transcription factor 19bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010111-1
    See related
    Ensembl:ENSDARG00000040266 AllianceGenome:ZFIN:ZDB-GENE-010111-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb174; sox31; fb76c08; fe16f11; fe24f11; sb:cb174; id:ibd3529; wu:fb76c08; wu:fe16f11; wu:fe24f11
    Summary
    Contributes to DNA-binding transcription factor activity. Involved in neural crest cell differentiation and neural tube development. Acts upstream of or within several processes, including dorsal/ventral axis specification; epiboly involved in gastrulation with mouth forming second; and positive regulation of DNA-binding transcription factor activity. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; neural keel; neural rod; neural tube; and presumptive structure. Orthologous to human SOX15 (SRY-box transcription factor 15). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See sox19b in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (26494585..26497947, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (26223392..26226754, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene metallo-beta-lactamase domain containing 1 Neighboring gene mannose-P-dolichol utilization defect 1b Neighboring gene small nucleolar RNA SNORD10 Neighboring gene eukaryotic translation initiation factor 4A1A Neighboring gene SUMO specific peptidase 3b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription regulator complex IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor Sox-19b
    Names
    SRY (sex determining region Y)-box 19b
    SRY-box containing gene 19b
    SRY-box containing gene 31
    protein sox-31
    transcription factor SOX19B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131702.1NP_571777.1  transcription factor Sox-19b

      See identical proteins and their annotated locations for NP_571777.1

      Status: PROVISIONAL

      Source sequence(s)
      AB242332
      UniProtKB/Swiss-Prot
      Q2Z1Q8, Q9DDD7
      Related
      ENSDARP00000058909.5, ENSDART00000058910.6
      Conserved Domains (2) summary
      cd01388
      Location:52123
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam12336
      Location:122203
      SOXp; SOX transcription factor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      26494585..26497947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)