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    rbfox2 RNA binding fox-1 homolog 2 [ Danio rerio (zebrafish) ]

    Gene ID: 406569, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rbfox2provided by ZNC
    Official Full Name
    RNA binding fox-1 homolog 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2464
    See related
    Ensembl:ENSDARG00000052182 AllianceGenome:ZFIN:ZDB-GENE-040426-2464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rbm9; zgc:85694
    Summary
    Predicted to enable RNA binding activity. Acts upstream of or within regulation of RNA splicing and striated muscle tissue development. Predicted to be located in nucleus. Is expressed in several structures, including muscle; pectoral fin bud; segmental plate; skeletal muscle satellite cell; and tail bud. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RBFOX2 (RNA binding fox-1 homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rbfox2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (296072..342217)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (278079..322320)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptor 4 Neighboring gene G-protein coupled receptor 35-like Neighboring gene retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Neighboring gene phosphodiesterase 6H, cGMP-specific, cone, gamma, paralog a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. In vivo assessment of contractile strength distinguishes differential gene function in skeletal muscle of zebrafish larvae. Martin BL, et al. J Appl Physiol (1985), 2015 Oct 1. PMID 26251513, Free PMC Article
    2. Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish. Berberoglu MA, et al. Dev Biol, 2017 Apr 15. PMID 28279710, Free PMC Article
    3. Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models. Antón-Galindo E, et al. Transl Psychiatry, 2024 Feb 19. PMID 38374212, Free PMC Article
    4. RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure. Gao C, et al. J Clin Invest, 2016 Jan. PMID 26619120, Free PMC Article
    5. RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish. Frese KS, et al. J Cell Sci, 2015 Aug 15. PMID 26116573, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Rbfox1l and Rbfox2 have unique and redundant roles in splicing regulation.
      Title: Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cardiac muscle cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within left ventricular cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of RNA splicing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within skeletal muscle fiber development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA binding protein fox-1 homolog 2
    Names
    RNA binding motif protein 9
    RNA binding protein, fox-1 homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214746.2 → NP_999911.2  RNA binding protein fox-1 homolog 2

      Status: VALIDATED

      Source sequence(s)
      LO017833, LO018681
      UniProtKB/TrEMBL
      A0A8M9QA95

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      296072..342217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476827.2 → XP_021332502.1  RNA binding protein fox-1 homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PM01
      Conserved Domains (2) summary
      cd12407
      Location:166 → 241
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:285 → 386
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    2. XM_021476829.2 → XP_021332504.1  RNA binding protein fox-1 homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q615
      Conserved Domains (2) summary
      cd12407
      Location:166 → 241
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:285 → 350
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    3. XM_021476828.2 → XP_021332503.1  RNA binding protein fox-1 homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PZL7
      Conserved Domains (2) summary
      cd12407
      Location:133 → 208
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:252 → 353
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    RNA

    1. XR_002458996.2 RNA Sequence

      Related
      ENSDART00000073985.5
    Nucleotide Protein
    Heading Accession and Version

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