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    usp36 ubiquitin specific peptidase 36 [ Danio rerio (zebrafish) ]

    Gene ID: 327239, updated on 9-Dec-2024

    Summary

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    Official Symbol
    usp36provided by ZNC
    Official Full Name
    ubiquitin specific peptidase 36provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5450
    See related
    Ensembl:ENSDARG00000032327 AllianceGenome:ZFIN:ZDB-GENE-030131-5450
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    usp37; wu:fd19b04
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within cranial skeletal system development. Predicted to be active in cytosol and nucleus. Orthologous to human USP36 (ubiquitin specific peptidase 36). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See usp36 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (57583653..57630791, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (57513129..57560267, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 3a Neighboring gene cytohesin 1a Neighboring gene uncharacterized LOC101883359 Neighboring gene TIMP metallopeptidase inhibitor 2b Neighboring gene galectin 3 binding protein, tandem duplicate 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Importance of deubiquitinases in zebrafish craniofacial development. Tse WKF. Biochem Biophys Res Commun, 2017 Jun 10. PMID 28450118
    2. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. Liongue C, et al. PLoS One, 2012. PMID 22412924, Free PMC Article
    3. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
    4. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cranial skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 36
    NP_001292509.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305580.1 → NP_001292509.1  ubiquitin carboxyl-terminal hydrolase 36

      Status: VALIDATED

      Source sequence(s)
      CT573423
      UniProtKB/TrEMBL
      A0A8M1P6D7, E7F4C0
      Related
      ENSDARP00000111119.2, ENSDART00000129598.3
      Conserved Domains (4) summary
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl19000
      Location:888 → 1090
      Cas10_III; CRISPR/Cas system-associated protein Cas10
      pfam00443
      Location:122 → 420
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam15279
      Location:610 → 746
      SOBP; Sine oculis-binding protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      57583653..57630791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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