psmd10 proteasome 26S subunit, non-ATPase 10 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: psmd10provided by ZNC
Official Full Name: proteasome 26S subunit, non-ATPase 10provided by ZNC
Primary source: ZFIN:ZDB-GENE-050112-1
See related: Ensembl:ENSDARG00000015628 AllianceGenome:ZFIN:ZDB-GENE-050112-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gankyrin; zgc:109707
Summary: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within lipid homeostasis; regulation of apoptotic process; and regulation of cell population proliferation. Predicted to be part of proteasome complex. Predicted to be active in nucleus. Orthologous to human PSMD10 (proteasome 26S subunit, non-ATPase 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (28464754..28468991)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (28158796..28163033)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gankyrin expression promotes spontaneous cancer and non-cancerous liver diseases. Gankyrin accelerates liver steatosis, cholangitis, fibrosis, and hepatocarcinogenesis with persistent damage and proliferation in hepatocytes.
Title: Inducible liver-specific overexpression of gankyrin in zebrafish results in spontaneous intrahepatic cholangiocarcinoma and hepatocellular carcinoma formation.
This study is the first to report gankyrin as a potential link between microRNAs and liver steatosis in zebrafish.
Title: Overexpression of gankyrin induces liver steatosis in zebrafish (Danio rerio).

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General gene information

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Markers

fk32a11.y1 (e-PCR)
- UniSTS:200814

fd60f08.x1 (e-PCR)
- UniSTS:195805

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 10

Names: gank; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205754.1 → NP_991317.1 26S proteasome non-ATPase regulatory subunit 10

See identical proteins and their annotated locations for NP_991317.1

Status: PROVISIONAL

Source sequence(s)

AY398401

UniProtKB/TrEMBL

A6XBK6, Q6TGV5

Related

ENSDARP00000010745.5, ENSDART00000019003.6

Conserved Domains (5) summary

smart00248
Location:39 → 68

ANK; ankyrin repeats

cd00204
Location:67 → 192

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:44 → 136

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:13 → 60

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:105 → 136

ANK; ANK repeat [structural motif]