U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pigr polymeric immunoglobulin receptor [ Danio rerio (zebrafish) ]

    Gene ID: 566471, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    pigrprovided by ZNC
    Official Full Name
    polymeric immunoglobulin receptorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-327
    See related
    Ensembl:ENSDARG00000101890 AllianceGenome:ZFIN:ZDB-GENE-060503-327
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-9d9.6
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. Is expressed in ovary. Orthologous to human FCAMR (Fc alpha and mu receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See pigr in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (51613453..51634478, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (52020691..52041888, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:ch211-9d9.7 Neighboring gene polymeric immunoglobulin receptor Neighboring gene defender against cell death 1 Neighboring gene abhydrolase domain containing 4, N-acyl phospholipase B

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. New Insights into IgZ as a Maternal Transfer Ig Contributing to the Early Defense of Fish against Pathogen Infection. Ji JF, et al. J Immunol, 2021 May 1. PMID 33858963
    2. Identification and expression of a new Ly6 gene cluster in zebrafish Danio rerio, with implications of being involved in embryonic immunity. Wang M, et al. Fish Shellfish Immunol, 2016 Jul. PMID 27071517
    3. Application of Biomimetic Cell-Derived Nanoparticles with Mannose Modification as a Novel Vaccine Delivery Platform against Teleost Fish Viral Disease. Zhang C, et al. ACS Biomater Sci Eng, 2020 Dec 14. PMID 33320639
    4. Differential expression and ligand binding indicate alternative functions for zebrafish polymeric immunoglobulin receptor (pIgR) and a family of pIgR-like (PIGRL) proteins. Kortum AN, et al. Immunogenetics, 2014 Apr. PMID 24469064, Free PMC Article
    5. Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. Zhang C, et al. ACS Appl Mater Interfaces, 2024 Jan 10. PMID 38055273

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A single pigr gene has been identified on chromosome 2 along with a large multigene family consisting of 29 pigr-like (PIGRL) genes.
      Title: Differential expression and ligand binding indicate alternative functions for zebrafish polymeric immunoglobulin receptor (pIgR) and a family of pIgR-like (PIGRL) proteins.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    polymeric immunoglobulin receptor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302250.1 → NP_001289179.1  polymeric immunoglobulin receptor precursor

      See identical proteins and their annotated locations for NP_001289179.1

      Status: PROVISIONAL

      Source sequence(s)
      KF932325
      Related
      ENSDARP00000141970.1, ENSDART00000165568.2
      Conserved Domains (2) summary
      cd05716
      Location:139 → 231
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:26 → 127
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      51613453..51634478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163603.5 → XP_005163660.1  polymeric immunoglobulin receptor isoform X1

      Conserved Domains (2) summary
      cd05716
      Location:139 → 231
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:26 → 127
      IG_like; Immunoglobulin like
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.