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    gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [ Danio rerio (zebrafish) ]

    Gene ID: 406367, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gapdhsprovided by ZNC
    Official Full Name
    glyceraldehyde-3-phosphate dehydrogenase, spermatogenicprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020913-1
    See related
    Ensembl:ENSDARG00000039914 AllianceGenome:ZFIN:ZDB-GENE-020913-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb350; g3pdh; gapdh; gapds; fb71f08; fk58c09; gapdh-2; zgc:76908; wu:fb71f08; wu:fk58c09
    Summary
    Predicted to enable glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Predicted to be involved in glycolytic process. Predicted to act upstream of or within glucose metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including cardiovascular system; digestive system; female organism; nervous system; and neural tube. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDHS (glyceraldehyde-3-phosphate dehydrogenase, spermatogenic). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gapdhs in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (45044642..45069814, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (45077926..45103098, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 2, cytosolic sulfotransferase 3 Neighboring gene transmembrane protein 147 Neighboring gene si:rp71-77l1.2 Neighboring gene si:rp71-77l1.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Active mechanistic target of rapamycin plays an ancillary rather than essential role in zebrafish CNS axon regeneration. Diekmann H, et al. Front Cell Neurosci, 2015. PMID 26217179, Free PMC Article
    2. Dnmt3aa but Not Dnmt3ab Is Required for Maintenance of Gametogenesis in Nile Tilapia (Oreochromis niloticus). Wang F, et al. Int J Mol Sci, 2021 Sep 21. PMID 34576333, Free PMC Article
    3. Construction of cytoplasmic molecular markers distinguishing Danio rerio from Gobiocypris rarus at high identity domains based on MP-PCR strategy and Sybr Green I detection. Pei DS, et al. Mol Biol Rep, 2008 Mar. PMID 17211516
    4. Semaphorin4D promotes axon regrowth and swimming ability during recovery following zebrafish spinal cord injury. Peng SX, et al. Neuroscience, 2017 May 20. PMID 28347780
    5. Prolonged Piezo1 Activation Induces Cardiac Arrhythmia. Rolland L, et al. Int J Mol Sci, 2023 Apr 4. PMID 37047693, Free PMC Article

    See all (166) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glyceraldehyde-3-phosphate dehydrogenase 2
    Names
    glyceraldehyde 3-phosphate dehydrogenase, testis-specific
    spermatogenic glyceraldehyde-3-phosphate dehydrogenase
    NP_998259.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213094.2 → NP_998259.1  glyceraldehyde-3-phosphate dehydrogenase 2

      See identical proteins and their annotated locations for NP_998259.1

      Status: PROVISIONAL

      Source sequence(s)
      BC154822
      UniProtKB/Swiss-Prot
      Q5MJ86
      Related
      ENSDARP00000058383.5, ENSDART00000058384.6
      Conserved Domains (3) summary
      COG0057
      Location:6 → 331
      GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
      pfam00044
      Location:6 → 152
      Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
      pfam02800
      Location:157 → 314
      Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      45044642..45069814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5MJ86.1 GenPept UniProtKB/Swiss-Prot:Q5MJ86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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