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    Otud5 OTU domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 54644, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Otud5provided by MGI
    Official Full Name
    OTU domain containing 5provided by MGI
    Primary source
    MGI:MGI:1859615
    See related
    Ensembl:ENSMUSG00000031154 AllianceGenome:MGI:1859615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DUBA; Sfc7; DXImx46e
    Summary
    Predicted to enable K48-linked deubiquitinase activity; K63-linked deubiquitinase activity; and cysteine-type deubiquitinase activity. Acts upstream of or within several processes, including alpha-beta T cell differentiation; negative regulation of interleukin-17 production; and regulation of T-helper 17 type immune response. Predicted to be located in nucleus. Orthologous to human OTUD5 (OTU deubiquitinase 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 21.1), spleen adult (RPKM 18.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Otud5 in Genome Data Viewer
    Location:
    X A1.1; X 3.54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7705852..7742861)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7839613..7876626)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene GRIP1 associated protein 1 Neighboring gene microRNA 1198 Neighboring gene potassium voltage-gated channel, Shal-related family, member 1 Neighboring gene STARR-seq mESC enhancer starr_46674 Neighboring gene STARR-positive B cell enhancer ABC_E11045 Neighboring gene proviral integration site 2 Neighboring gene solute carrier family 35 (UDP-galactose transporter), member A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury. Zhao Y, et al. Nat Commun, 2024 Jun 27. PMID 38937512, Free PMC Article
    2. OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation. Liu Y, et al. Cell Death Differ, 2024 Jun. PMID 38605168, Free PMC Article
    3. USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling. Tang Y, et al. Int J Radiat Oncol Biol Phys, 2024 Jul 15. PMID 38364946
    4. Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis. Dai J, et al. Cell Mol Gastroenterol Hepatol, 2024. PMID 38036082, Free PMC Article
    5. Phosphorylation-dependent activity of the deubiquitinase DUBA. Huang OW, et al. Nat Struct Mol Biol, 2012 Jan 15. PMID 22245969

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury.
      Title: Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury.
    2. USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling.
      Title: USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling.
    3. OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation.
      Title: OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation.
    4. Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis.
      Title: Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis.
    5. OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING.
      Title: OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING.
    6. OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity.
      Title: OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity.
    7. data identify DUBA as a cell-intrinsic suppressor of IL-17 production
      Title: Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12550

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables K48-linked deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables K63-linked deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within T-helper 17 cell lineage commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within interleukin-21 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within interleukin-9 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of interleukin-17 production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-17 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neural crest cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural crest cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC2 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of T-helper 17 type immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    OTU domain-containing protein 5
    Names
    deubiquinating enzyme A
    deubiquitinating enzyme A
    NP_001277465.1
    NP_001277466.1
    NP_001413225.1
    NP_001413227.1
    NP_613070.2
    XP_006527728.1
    XP_006527729.1
    XP_030107258.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290536.2 → NP_001277465.1  OTU domain-containing protein 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 both encode the same isoform (1).
      Source sequence(s)
      AL671978, AL671995
      Consensus CDS
      CCDS72336.1
      UniProtKB/TrEMBL
      A2AES4, A2AES5
      Related
      ENSMUSP00000111330.2, ENSMUST00000115666.8
      Conserved Domains (1) summary
      cl19932
      Location:221 → 332
      OTU; OTU-like cysteine protease

    2. NM_001290537.2 → NP_001277466.1  OTU domain-containing protein 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame segment of the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL671978, AL671995
      Consensus CDS
      CCDS72335.1
      UniProtKB/TrEMBL
      A2AES3
      Related
      ENSMUSP00000111332.4, ENSMUST00000115668.10
      Conserved Domains (1) summary
      cl19932
      Location:178 → 287
      OTU; OTU-like cysteine protease

    3. NM_001426296.1 → NP_001413225.1  OTU domain-containing protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL671978, AL671995
      UniProtKB/TrEMBL
      A2AES5

    4. NM_001426298.1 → NP_001413227.1  OTU domain-containing protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL671978, AL671995
      UniProtKB/Swiss-Prot
      Q3U2S4, Q3UE33, Q91YL5, Q9CV50, Q9JIG6

    5. NM_138604.4 → NP_613070.2  OTU domain-containing protein 5 isoform 2

      See identical proteins and their annotated locations for NP_613070.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 5 both encode the same isoform (2).
      Source sequence(s)
      AL671978, AL671995
      Consensus CDS
      CCDS29975.1
      UniProtKB/Swiss-Prot
      Q3U2S4, Q3UE33, Q91YL5, Q9CV50, Q9JIG6
      UniProtKB/TrEMBL
      A2AES4
      Related
      ENSMUSP00000033494.10, ENSMUST00000033494.16
      Conserved Domains (1) summary
      cl19932
      Location:221 → 332
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      7705852..7742861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527666.4 → XP_006527729.1  OTU domain-containing protein 5 isoform X4

      UniProtKB/TrEMBL
      A2AES4
      Conserved Domains (1) summary
      cl19932
      Location:221 → 332
      OTU; OTU-like cysteine protease

    2. XM_006527665.5 → XP_006527728.1  OTU domain-containing protein 5 isoform X3

      UniProtKB/TrEMBL
      A2AES4
      Conserved Domains (1) summary
      cl19932
      Location:220 → 331
      OTU; OTU-like cysteine protease

    3. XM_030251398.2 → XP_030107258.1  OTU domain-containing protein 5 isoform X5

      UniProtKB/TrEMBL
      A2AES3
      Conserved Domains (1) summary
      cl19932
      Location:177 → 288
      OTU; OTU-like cysteine protease
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U2S4.2 GenPept UniProtKB/Swiss-Prot:Q3U2S4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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