Slc30a5 solute carrier family 30 (zinc transporter), member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc30a5provided by MGI
Official Full Name: solute carrier family 30 (zinc transporter), member 5provided by MGI
Primary source: MGI:MGI:1916298
See related: Ensembl:ENSMUSG00000021629 AllianceGenome:MGI:1916298
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZNT5; ZTL1; ZnT-5; Zntl1; 1810010K08Rik
Summary: Predicted to enable zinc efflux transmembrane transporter activity and zinc:proton antiporter activity. Predicted to be involved in several processes, including insulin processing; intracellular zinc ion homeostasis; and zinc ion transmembrane transport. Predicted to act upstream of with a positive effect on GPI anchor biosynthetic process. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle membrane; and nuclear lumen. Predicted to be active in Golgi apparatus and cytoplasmic vesicle. Is expressed in craniocervical region bone; submandibular gland primordium; and thoracic segment skeleton. Orthologous to human SLC30A5 (solute carrier family 30 member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 20.1), large intestine adult (RPKM 17.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 53.23 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (100939153..100969988, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (100802645..100833480, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that Znt5 is selectively required for the mast cell-mediated delayed-type allergic response, and it is a novel player in mast cell activation.
Title: Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction.
ZnT5(-)ZnT7(-/-) cells showed exacerbation of the unfolded protein response as did the wild-type cells cultured under a zinc-deficient condition, revealing that both complexes play a role in homeostatic maintenance of secretory pathway function
Title: Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells.
results indicate that Znt5 protein plays an important role in maturation of osteoblasts and in maintenance of the cells involved in the cardiac conduction system, partly owing to dysregulated expression of IEGs and HSPs
Title: Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc30a5 (e-PCR), detects polymorphism
- UniSTS:547078

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables zinc:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables zinc:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect GPI anchor biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect GPI anchor biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cobalt ion transport	IEA Inferred from Electronic Annotation more info
involved_in insulin processing	ISO Inferred from Sequence Orthology more info	PubMed
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in response to zinc ion	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into Golgi lumen	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion import into Golgi lumen	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into Golgi lumen	ISS Inferred from Sequence or Structural Similarity more info
involved_in zinc ion import into organelle	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into organelle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within zinc ion transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in zinc ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in ER to Golgi transport vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in ER to Golgi transport vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi cis cisterna membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi cis cisterna membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in Golgi membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info	PubMed
located_in secretory granule membrane	ISO Inferred from Sequence Orthology more info
located_in secretory granule membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proton-coupled zinc antiporter SLC30A5

Names: solute carrier family 30 member 5; zinc transporter 5; zinc transporter like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022885.2 → NP_075023.2 proton-coupled zinc antiporter SLC30A5

See identical proteins and their annotated locations for NP_075023.2

Status: VALIDATED

Source sequence(s)

AF461761, AK051183

Consensus CDS

CCDS26739.1

UniProtKB/Swiss-Prot

Q8BQA0, Q8K315, Q8R4H9

UniProtKB/TrEMBL

A0A286YDV6

Related

ENSMUSP00000065764.5, ENSMUST00000067246.6

Conserved Domains (2) summary

TIGR01297
Location:426 → 725

CDF; cation diffusion facilitator family transporter

pfam01545
Location:426 → 645

Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

100939153..100969988 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158154.1 → XP_036014047.1 proton-coupled zinc antiporter SLC30A5 isoform X1

UniProtKB/TrEMBL

A0A286YDV6

Conserved Domains (1) summary

TIGR01297
Location:375 → 674

CDF; cation diffusion facilitator family transporter
XM_011244695.3 → XP_011242997.1 proton-coupled zinc antiporter SLC30A5 isoform X2

UniProtKB/TrEMBL

Q8C2T4

Conserved Domains (1) summary

TIGR01297
Location:331 → 630

CDF; cation diffusion facilitator family transporter
XM_036158156.1 → XP_036014049.1 proton-coupled zinc antiporter SLC30A5 isoform X3

UniProtKB/TrEMBL

Q9JKN2

Conserved Domains (1) summary

TIGR01297
Location:257 → 556

CDF; cation diffusion facilitator family transporter
XM_036158155.1 → XP_036014048.1 proton-coupled zinc antiporter SLC30A5 isoform X2

UniProtKB/TrEMBL

Q8C2T4

Conserved Domains (1) summary

TIGR01297
Location:331 → 630

CDF; cation diffusion facilitator family transporter