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    Enc1 ectodermal-neural cortex 1 [ Mus musculus (house mouse) ]

    Gene ID: 13803, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Enc1provided by MGI
    Official Full Name
    ectodermal-neural cortex 1provided by MGI
    Primary source
    MGI:MGI:109610
    See related
    Ensembl:ENSMUSG00000041773 AllianceGenome:MGI:109610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nrpb; PIG10
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in several processes, including negative regulation of translation; positive regulation of neuron projection development; and proteasomal ubiquitin-independent protein catabolic process. Predicted to be located in chromatin; neuronal cell body; and nuclear lumen. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human ENC1 (ectodermal-neural cortex 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 112.0), whole brain E14.5 (RPKM 85.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Enc1 in Genome Data Viewer
    Location:
    13 50.66 cM; 13 D1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (97377613..97389548)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (97241105..97253040)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 169, member A Neighboring gene STARR-positive B cell enhancer ABC_E3094 Neighboring gene NSA2 ribosome biogenesis homolog Neighboring gene G elongation factor, mitochondrial 2 Neighboring gene STARR-seq mESC enhancer starr_35367 Neighboring gene hexosaminidase B Neighboring gene STARR-seq mESC enhancer starr_35370 Neighboring gene STARR-seq mESC enhancer starr_35377 Neighboring gene predicted gene, 33390 Neighboring gene STARR-seq mESC enhancer starr_35381 Neighboring gene STARR-seq mESC enhancer starr_35383 Neighboring gene predicted gene, 33447

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assignment of the ectodermal-neural cortex 1 gene (Enc1) to mouse chromosome band 13D1 by fluorescence in situ hybridization. Hernandez M, et al. Cytogenet Cell Genet, 2000. PMID 10965111
    2. Pallial expression of Enc1 RNA in postnatal mouse telencephalon. García-Calero E, et al. Brain Res Bull, 2005 Sep 15. PMID 16144629
    3. ENC-1: a novel mammalian kelch-related gene specifically expressed in the nervous system encodes an actin-binding protein. Hernandez MC, et al. J Neurosci, 1997 May 1. PMID 9096139, Free PMC Article
    4. Ectodermal-Neural Cortex 1 Isoforms Have Contrasting Effects on MC3T3-E1 Osteoblast Mineralization and Gene Expression. Worton LE, et al. J Cell Biochem, 2017 Aug. PMID 27996212
    5. NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation. Kim TA, et al. J Cell Biol, 1998 May 4. PMID 9566959, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasomal ubiquitin-independent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasomal ubiquitin-independent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasomal ubiquitin-independent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ectoderm-neural cortex protein 1
    Names
    ENC-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007930.4 → NP_031956.3  ectoderm-neural cortex protein 1

      See identical proteins and their annotated locations for NP_031956.3

      Status: VALIDATED

      Source sequence(s)
      AK132173, AV465735
      Consensus CDS
      CCDS26710.1
      UniProtKB/Swiss-Prot
      O35709, Q8C7V2
      UniProtKB/TrEMBL
      Q8BRG4
      Related
      ENSMUSP00000038783.8, ENSMUST00000041623.9
      Conserved Domains (4) summary
      PHA03098
      Location:48 → 566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 374
      Kelch; KELCH repeat [structural motif]
      cd18267
      Location:6 → 152
      BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
      cd18515
      Location:145 → 242
      BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      97377613..97389548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247139.1 → XP_030102999.1  ectoderm-neural cortex protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O35709, Q8C7V2
      UniProtKB/TrEMBL
      Q8BRG4
      Conserved Domains (4) summary
      PHA03098
      Location:48 → 566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 374
      Kelch; KELCH repeat [structural motif]
      cd18267
      Location:6 → 152
      BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
      cd18515
      Location:145 → 242
      BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)

    2. XM_030247137.1 → XP_030102997.1  ectoderm-neural cortex protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O35709, Q8C7V2
      UniProtKB/TrEMBL
      Q8BRG4
      Conserved Domains (4) summary
      PHA03098
      Location:48 → 566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 374
      Kelch; KELCH repeat [structural motif]
      cd18267
      Location:6 → 152
      BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
      cd18515
      Location:145 → 242
      BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)

    3. XM_030247138.1 → XP_030102998.1  ectoderm-neural cortex protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O35709, Q8C7V2
      UniProtKB/TrEMBL
      Q8BRG4
      Conserved Domains (4) summary
      PHA03098
      Location:48 → 566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 374
      Kelch; KELCH repeat [structural motif]
      cd18267
      Location:6 → 152
      BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
      cd18515
      Location:145 → 242
      BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35709.2 GenPept UniProtKB/Swiss-Prot:O35709

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