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    TMEM204 transmembrane protein 204 [ Homo sapiens (human) ]

    Gene ID: 79652, updated on 9-Dec-2024

    Summary

    Official Symbol
    TMEM204provided by HGNC
    Official Full Name
    transmembrane protein 204provided by HGNC
    Primary source
    HGNC:HGNC:14158
    See related
    Ensembl:ENSG00000131634 MIM:611002; AllianceGenome:HGNC:14158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLP24; C16orf30
    Summary
    C16ORF30 plays a role in cell adhesion and cellular permeability at adherens junctions (Kearsey et al., 2004 [PubMed 15206924]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in fat (RPKM 31.7), lung (RPKM 12.9) and 21 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TMEM204 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1528678..1555568)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1543710..1570600)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1578679..1605569)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1543166-1544066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1544968-1545868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1545869-1546768 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_42864 Neighboring gene pentraxin 4 Neighboring gene telomere maintenance 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:1574508-1575707 Neighboring gene intraflagellar transport 140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1582993-1583696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1583697-1584400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1592422-1593124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1605115-1605614 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1609654-1609839 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1611806-1612415 Neighboring gene uncharacterized LOC105371046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1662256-1662756 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1662757-1663257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10230 Neighboring gene cramped chromatin regulator homolog 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1696049-1696268 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1701290-1701464 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1728137-1728772

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ20898, MGC111564

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in lymph vessel development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of vascular endothelial growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in smooth muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transmembrane protein 204
    Names
    claudin-like protein 24
    claudin-like protein of 24 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256541.2NP_001243470.1  transmembrane protein 204

      See identical proteins and their annotated locations for NP_001243470.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AL031719, BC004932, BC105785
      Consensus CDS
      CCDS42098.1
      UniProtKB/Swiss-Prot
      D3DU76, Q3KRC1, Q9BSN7, Q9H7G5
      Related
      ENSP00000253934.5, ENST00000253934.9
    2. NM_024600.6NP_078876.2  transmembrane protein 204

      See identical proteins and their annotated locations for NP_078876.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AY676494, BC105785
      Consensus CDS
      CCDS42098.1
      UniProtKB/Swiss-Prot
      D3DU76, Q3KRC1, Q9BSN7, Q9H7G5
      Related
      ENSP00000454945.1, ENST00000566264.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      1528678..1555568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      1543710..1570600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)