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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_012856.2 RefSeqGene
- Range
-
4851..49128
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_1128
mRNA and Protein(s)
-
NM_001289000.2 → NP_001275929.1 transmembrane protease serine 6 isoform 1
See identical proteins and their annotated locations for NP_001275929.1
Status: REVIEWED
- Source sequence(s)
-
AL022314, AW295507
- Consensus CDS
-
CCDS74857.1
- UniProtKB/Swiss-Prot
- B0QYB4, B0QYB7, B0QYB8, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8
- Related
- ENSP00000384964.1, ENST00000406856.7
- Conserved Domains (5) summary
-
- cd00041
Location:326 → 440
- CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
- cd00112
Location:486 → 516
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cd00190
Location:568 → 822
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- pfam00057
Location:520 → 557
- Ldl_recept_a; Low-density lipoprotein receptor domain class A
- pfam01390
Location:77 → 177
- SEA; SEA domain
-
NM_001289001.2 → NP_001275930.1 transmembrane protease serine 6 isoform 3
See identical proteins and their annotated locations for NP_001275930.1
Status: REVIEWED
- Source sequence(s)
-
AL022314, AW295507, AY358398
- Consensus CDS
-
CCDS74856.1
- UniProtKB/Swiss-Prot
- B0QYB4, B0QYB7, B0QYB8, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8
- Related
- ENSP00000385453.1, ENST00000406725.6
- Conserved Domains (5) summary
-
- cd00041
Location:326 → 440
- CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
- cd00112
Location:486 → 516
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cd00190
Location:568 → 800
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- pfam00057
Location:520 → 557
- Ldl_recept_a; Low-density lipoprotein receptor domain class A
- pfam01390
Location:77 → 134
- SEA; SEA domain
-
NM_001374504.1 → NP_001361433.1 transmembrane protease serine 6 isoform 3
Status: REVIEWED
- Source sequence(s)
-
AL022314
- Consensus CDS
-
CCDS74856.1
- UniProtKB/Swiss-Prot
- B0QYB4, B0QYB7, B0QYB8, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8
- Related
- ENSP00000501573.1, ENST00000676104.1
- Conserved Domains (5) summary
-
- cd00041
Location:326 → 440
- CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
- cd00112
Location:486 → 516
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cd00190
Location:568 → 800
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- pfam00057
Location:520 → 557
- Ldl_recept_a; Low-density lipoprotein receptor domain class A
- pfam01390
Location:77 → 134
- SEA; SEA domain
-
NM_153609.4 → NP_705837.2 transmembrane protease serine 6 isoform 3
Status: REVIEWED
- Source sequence(s)
-
AL022314
- Consensus CDS
-
CCDS74856.1
- UniProtKB/Swiss-Prot
- B0QYB4, B0QYB7, B0QYB8, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8
- Related
- ENSP00000334962.6, ENST00000346753.9
- Conserved Domains (5) summary
-
- cd00041
Location:326 → 440
- CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
- cd00112
Location:486 → 516
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cd00190
Location:568 → 800
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- pfam00057
Location:520 → 557
- Ldl_recept_a; Low-density lipoprotein receptor domain class A
- pfam01390
Location:77 → 134
- SEA; SEA domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000022.11 Reference GRCh38.p14 Primary Assembly
- Range
-
37065436..37110536 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_024452167.2 → XP_024307935.1 transmembrane protease serine 6 isoform X1
- UniProtKB/Swiss-Prot
- B0QYB4, B0QYB7, B0QYB8, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8
- Related
- ENSP00000371211.2, ENST00000381792.6
- Conserved Domains (5) summary
-
- cd00041
Location:326 → 440
- CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
- cd00112
Location:486 → 516
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cd00190
Location:568 → 822
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- pfam00057
Location:520 → 557
- Ldl_recept_a; Low-density lipoprotein receptor domain class A
- pfam01390
Location:77 → 177
- SEA; SEA domain
-
XM_047441170.1 → XP_047297126.1 transmembrane protease serine 6 isoform X3
- UniProtKB/Swiss-Prot
- B0QYB4, B0QYB7, B0QYB8, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8
-
XM_011529989.3 → XP_011528291.1 transmembrane protease serine 6 isoform X2
- UniProtKB/Swiss-Prot
- B0QYB4, B0QYB7, B0QYB8, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8
- Conserved Domains (6) summary
-
- smart00020
Location:423 → 675
- Tryp_SPc; Trypsin-like serine protease
- cd00112
Location:342 → 372
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cd00190
Location:424 → 678
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- pfam00057
Location:376 → 413
- Ldl_recept_a; Low-density lipoprotein receptor domain class A
- pfam01390
Location:77 → 134
- SEA; SEA domain
- cl00049
Location:182 → 296
- CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
-
XM_047441171.1 → XP_047297127.1 transmembrane protease serine 6 isoform X3
- UniProtKB/Swiss-Prot
- B0QYB4, B0QYB7, B0QYB8, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8
-
XM_024452168.2 → XP_024307936.1 transmembrane protease serine 6 isoform X1
- UniProtKB/Swiss-Prot
- B0QYB4, B0QYB7, B0QYB8, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8
- Conserved Domains (5) summary
-
- cd00041
Location:326 → 440
- CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
- cd00112
Location:486 → 516
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cd00190
Location:568 → 822
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- pfam00057
Location:520 → 557
- Ldl_recept_a; Low-density lipoprotein receptor domain class A
- pfam01390
Location:77 → 177
- SEA; SEA domain
Alternate T2T-CHM13v2.0
Genomic
-
NC_060946.1 Alternate T2T-CHM13v2.0
- Range
-
37525034..37570488 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054325197.1 → XP_054181172.1 transmembrane protease serine 6 isoform X1
- UniProtKB/Swiss-Prot
- B0QYB4, B0QYB7, B0QYB8, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8
-
XM_054325199.1 → XP_054181174.1 transmembrane protease serine 6 isoform X3
- UniProtKB/Swiss-Prot
- B0QYB4, B0QYB7, B0QYB8, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8
-
XM_054325198.1 → XP_054181173.1 transmembrane protease serine 6 isoform X2
- UniProtKB/Swiss-Prot
- B0QYB4, B0QYB7, B0QYB8, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8
-
XM_054325200.1 → XP_054181175.1 transmembrane protease serine 6 isoform X3
- UniProtKB/Swiss-Prot
- B0QYB4, B0QYB7, B0QYB8, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8
-
XM_054325196.1 → XP_054181171.1 transmembrane protease serine 6 isoform X1
- UniProtKB/Swiss-Prot
- B0QYB4, B0QYB7, B0QYB8, Q5TI06, Q6ICC2, Q6UXD8, Q8IU80, Q8IUE2, Q8IXV8
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_153019.2: Suppressed sequence
- Description
- NM_153019.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.