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    TPM1 tropomyosin 1 [ Homo sapiens (human) ]

    Gene ID: 7168, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TPM1provided by HGNC
    Official Full Name
    tropomyosin 1provided by HGNC
    Primary source
    HGNC:HGNC:12010
    See related
    Ensembl:ENSG00000140416 MIM:191010; AllianceGenome:HGNC:12010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CMH3; TMSA; CMD1Y; LVNC9; C15orf13; HEL-S-265; HTM-alpha
    Summary
    This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022]
    Expression
    Biased expression in heart (RPKM 615.8), prostate (RPKM 140.5) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TPM1 in Genome Data Viewer
    Location:
    15q22.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (63042747..63071915)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (60846575..60875760)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (63334946..63364114)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene talin 2 Neighboring gene uncharacterized LOC105370854 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:63126856-63128055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63137585-63138085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63138767-63139268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63139269-63139768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63167575-63168413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:63189794-63190559 Neighboring gene Y-box-binding protein 1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63253469-63253969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:63281148-63281648 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:63281649-63282149 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:63333890-63334804 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:63335718-63336631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:63370949-63371626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:63371627-63372302 Neighboring gene VISTA enhancer hs2160 Neighboring gene TPM1 antisense RNA Neighboring gene Sharpr-MPRA regulatory region 14461 Neighboring gene uncharacterized LOC107984798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6509 Neighboring gene lactamase beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The regulatory effects of tropomyosin and troponin-I on the interaction of myosin loop regions with F-actin. Patchell VB, et al. J Biol Chem, 2005 Apr 15. PMID 15695827
    2. Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments. Robinson P, et al. Circ Res, 2007 Dec 7. PMID 17932326
    3. The cardiomyopathy-associated K15N mutation in tropomyosin alters actin filament pointed end dynamics. Colpan M, et al. Arch Biochem Biophys, 2017 Sep 15. PMID 28732641, Free PMC Article
    4. TPM1 is a Novel Predictive Biomarker for Gastric Cancer Diagnosis and Prognosis. Hu L, et al. Clin Lab, 2020 Apr 1. PMID 32255282
    5. Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy. Kuusisto J, et al. Heart, 2012 Jul. PMID 22447464, Free PMC Article

    See all (306) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impact of Troponin in Cardiomyopathy Development Caused by Mutations in Tropomyosin.
      Title: Impact of Troponin in Cardiomyopathy Development Caused by Mutations in Tropomyosin.
    2. MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1.
      Title: MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1.
    3. Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability.
      Title: Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability.
    4. The prognostic value of TPM1-4 in hepatocellular carcinoma.
      Title: The prognostic value of TPM1-4 in hepatocellular carcinoma.
    5. Genotype-phenotype correlations in hypertrophic cardiomyopathy: a multicenter study in Portugal and Spain of the TPM1 p.Arg21Leu variant.
      Title: Genotype-phenotype correlations in hypertrophic cardiomyopathy: a multicenter study in Portugal and Spain of the TPM1 p.Arg21Leu variant.
    6. Identification of a novel missense mutation in the TPM1 gene via exome sequencing in a Chinese family with dilated cardiomyopathy: A case report and literature review.
      Title: Identification of a novel missense mutation in the TPM1 gene via exome sequencing in a Chinese family with dilated cardiomyopathy: A case report and literature review.
    7. The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ.
      Title: The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ.
    8. Association Between TPM1 Gene Polymorphisms and Idiopathic Congenital Talipes Equinovarus Risk in a Chinese Population.
      Title: Association Between TPM1 Gene Polymorphisms and Idiopathic Congenital Talipes Equinovarus Risk in a Chinese Population.
    9. Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation.
      Title: Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation.
    10. Circ0001320 inhibits lung cancer cell growth and invasion by regulating TNFAIP1 and TPM1 expression through sponging miR-558.
      Title: Circ0001320 inhibits lung cancer cell growth and invasion by regulating TNFAIP1 and TPM1 expression through sponging miR-558.
    Submit: New GeneRIF Correction See all GeneRIFs (120)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in TPM1 that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2015-11-09)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2015-11-09)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
    EBI GWAS Catalog
    Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
    EBI GWAS Catalog
    New gene functions in megakaryopoiesis and platelet formation.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Exposure of human skin fibroblasts to HIV-1 protease induces the degradation of the vimentin filament network and the disappearance of the tropomyosin isoforms microfilament network PubMed
    gag-pol HIV-1 protease cleaves tropomyosin in vitro at positions 30, 51, and 87 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cytoskeletal protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables structural constituent of muscle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to reactive oxygen species IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in muscle filament sliding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ATP-dependent activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of heart rate by epinephrine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of heart contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ruffle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventricular cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bleb IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of muscle thin filament tropomyosin TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcomere TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tropomyosin alpha-1 chain
    Names
    cardiomyopathy, hypertrophic 3
    epididymis secretory protein Li 265
    sarcomeric tropomyosin kappa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007557.1 RefSeqGene

      Range
      5109..28540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_387

    mRNA and Protein(s)

    1. NM_000366.6 → NP_000357.3  tropomyosin alpha-1 chain isoform Tpm1.5cy

      See identical proteins and their annotated locations for NP_000357.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.5, also known as variant 5) contains an alternate, in-frame exon and uses an alternate in-frame splice site and upstream stop codon, compared to variant Tpm1.1. It encodes isoform Tpm1.5cy, which has a different C-terminus, compared to isoform Tpm1.1st.
      Source sequence(s)
      AC079328, BC007433, BG107949, CN423344
      Consensus CDS
      CCDS10181.1
      UniProtKB/TrEMBL
      A0A0K0K1I0
      Related
      ENSP00000288398.6, ENST00000288398.10
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    2. NM_001018004.2 → NP_001018004.1  tropomyosin alpha-1 chain isoform Tpm1.6cy

      See identical proteins and their annotated locations for NP_001018004.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.6, also known as variant 3) contains an alternate, in-frame exon in the 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.6cy, also known as the TM-2 fibroblast isoform, which has a distinct C-terminus, compared to isoform Tpm1.1st.
      Source sequence(s)
      AC079328, AJ000147
      Consensus CDS
      CCDS58369.1
      UniProtKB/Swiss-Prot
      P09493
      UniProtKB/TrEMBL
      O15513
      Related
      ENSP00000453941.1, ENST00000559556.5
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    3. NM_001018005.2 → NP_001018005.1  tropomyosin alpha-1 chain isoform Tpm1.1st

      See identical proteins and their annotated locations for NP_001018005.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.1, also known as variant 1) represents the shortest transcript. It encodes the longest isoform (Tpm1.1st), also known as the fast skeletal muscle isoform.
      Source sequence(s)
      AC079328, BC007433, BG107949, M19713
      Consensus CDS
      CCDS45273.1
      UniProtKB/Swiss-Prot
      B7Z5T7, D9YZV2, D9YZV3, D9YZV8, P09493, P09494, P10469, Q6DV89, Q6DV90, Q7Z6L8, Q86W64, Q96IK2, Q9UCI1, Q9UCI2, Q9UCY9, Q9Y427
      UniProtKB/TrEMBL
      A0AAQ5BH79, D9YZV4
      Related
      ENSP00000385107.4, ENST00000403994.9
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    4. NM_001018006.2 → NP_001018006.1  tropomyosin alpha-1 chain isoform Tpm1.7cy

      See identical proteins and their annotated locations for NP_001018006.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.7, also known as variant 4) contains alternate, in-frame exons in the 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.7cy, also known as the TM-3 fibroblast isoform, which has a distinct C-terminus, compared to isoform Tpm1.1st.
      Source sequence(s)
      AC079328, AJ000147
      Consensus CDS
      CCDS32263.1
      UniProtKB/TrEMBL
      D9YZV5
      Related
      ENSP00000351022.3, ENST00000358278.7
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    5. NM_001018007.2 → NP_001018007.1  tropomyosin alpha-1 chain isoform Tpm1.4sm

      See identical proteins and their annotated locations for NP_001018007.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.4, also known as variant 2) contains alternate, in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.4sm, also known as the smooth muscle isoform, which has distinct N- and C-termini, compared to isoform Tpm1.1st.
      Source sequence(s)
      AL050179, BG107949
      Consensus CDS
      CCDS32262.1
      Related
      ENSP00000267996.7, ENST00000267996.11
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    6. NM_001018008.2 → NP_001018008.1  tropomyosin alpha-1 chain isoform Tpm1.12br

      See identical proteins and their annotated locations for NP_001018008.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.12, also known as variant 6) contains alternate in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.12br, also known as the TMBr-3 brain isoform, which has distinct N- and C-termini and is shorter than isoform Tpm1.1st.
      Source sequence(s)
      AC079328, BC050473, BC053545
      Consensus CDS
      CCDS32264.1
      UniProtKB/TrEMBL
      D9YZV7, Q59GR8
      Related
      ENSP00000334624.4, ENST00000334895.10
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 244
      Tropomyosin

    7. NM_001018020.2 → NP_001018020.1  tropomyosin alpha-1 chain isoform Tpm1.3sm

      See identical proteins and their annotated locations for NP_001018020.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.3, also known as variant 7) contains alternate, in-frame exons in the coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.3sm, which has distinct N- and C-termini, compared to isoform Tpm1.1st.
      Source sequence(s)
      AC079328, AJ000147, BG107949, BX458841
      Consensus CDS
      CCDS58368.1
      UniProtKB/Swiss-Prot
      P09493
      UniProtKB/TrEMBL
      O15513
      Related
      ENSP00000452879.1, ENST00000559397.6
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    8. NM_001301244.2 → NP_001288173.1  tropomyosin alpha-1 chain isoform Tpm1.2st

      See identical proteins and their annotated locations for NP_001288173.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.2, also known as variant 8) contains an alternate, in-frame exon in the 5' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.2st, which has a distinct N-terminus, compared to isoform Tpm1.1st.
      Source sequence(s)
      AC079328, AY640414, CD679271, CN423297
      Consensus CDS
      CCDS86459.1
      UniProtKB/Swiss-Prot
      P09493
      Related
      ENSP00000453955.2, ENST00000561266.6
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    9. NM_001301289.2 → NP_001288218.1  tropomyosin alpha-1 chain isoform Tpm1.8cy

      See identical proteins and their annotated locations for NP_001288218.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.8, also known as variant 9) contains alternate in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.8cy, which has distinct N- and C-termini and is shorter than isoform Tpm1.1st. Variants Tpm1.8, Tpm1.9 and Tpm1.13 encode isoforms that are the same length, but have distinct protein sequences.
      Source sequence(s)
      AC079328
      UniProtKB/TrEMBL
      B7Z722
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 246
      Tropomyosin

    10. NM_001330344.2 → NP_001317273.1  tropomyosin alpha-1 chain isoform Tpm1.9cy

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.9, also known as variant 10) contains alternate, in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.9cy, which has distinct N- and C-termini, compared to isoform Tpm1.1st. Variants Tpm1.8, Tpm1.9 and Tpm1.13 encode isoforms that are the same length, but have distinct protein sequences.
      Source sequence(s)
      AC079328, AL050179, AL558518
      Consensus CDS
      CCDS81892.1
      UniProtKB/TrEMBL
      H7BYY1
      Related
      ENSP00000384315.4, ENST00000404484.9
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 246
      Tropomyosin

    11. NM_001330346.2 → NP_001317275.1  tropomyosin alpha-1 chain isoform Tpm1.13

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.13, also known as variant 11) has a different 5' structure compared to variant Tpm1.1. It encodes isoform Tpm1.13, which has a distinct N-terminus, compared to isoform Tpm1.1st. Variants Tpm1.8, Tpm1.9 and Tpm1.13 encode isoforms that are the same length, but have distinct protein sequences.
      Source sequence(s)
      AC079328, BC007433
      Consensus CDS
      CCDS81894.1
      UniProtKB/TrEMBL
      H0YK48
      Related
      ENSP00000452658.1, ENST00000559281.6
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 246
      Tropomyosin

    12. NM_001330351.2 → NP_001317280.1  tropomyosin alpha-1 chain isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) contains alternate, in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform 12, which has distinct N- and C-termini, compared to isoform Tpm1.1st.
      Source sequence(s)
      AC079328, AL050179
      Consensus CDS
      CCDS81891.1
      UniProtKB/TrEMBL
      F5H7S3, Q1ZYL5
      Related
      ENSP00000322577.7, ENST00000317516.12
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 244
      Tropomyosin

    13. NM_001365776.1 → NP_001352705.1  tropomyosin alpha-1 chain isoform Tpm1.10br

      Status: REVIEWED

      Source sequence(s)
      AC079328
      Related
      ENST00000651344.1
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 280
      Tropomyosin

    14. NM_001365777.1 → NP_001352706.1  tropomyosin alpha-1 chain isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC079328
      Conserved Domains (2) summary
      pfam00261
      Location:48 → 259
      Tropomyosin
      pfam16526
      Location:13 → 72
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    15. NM_001365778.1 → NP_001352707.1  tropomyosin alpha-1 chain isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC079328, AK131384
      Consensus CDS
      CCDS92009.1
      UniProtKB/TrEMBL
      Q6ZN40
      Related
      ENSP00000350667.4, ENST00000357980.9
      Conserved Domains (2) summary
      TIGR00998
      Location:1 → 159
      8a0101; efflux pump membrane protein (multidrug resistance protein A)
      pfam00261
      Location:90 → 324
      Tropomyosin

    16. NM_001365779.1 → NP_001352708.1  tropomyosin alpha-1 chain isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC079328, M19714
      Consensus CDS
      CCDS92010.1
      UniProtKB/TrEMBL
      A0A0S2Z4G6, A0AAQ5BH79, H0YL52
      Related
      ENSP00000453062.2, ENST00000560970.6
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin; Tropomyosin

    17. NM_001365780.1 → NP_001352709.1  tropomyosin alpha-1 chain isoform Tpm1.11br

      Status: REVIEWED

      Source sequence(s)
      AC079328
      Consensus CDS
      CCDS92013.1
      UniProtKB/TrEMBL
      A0A494BZZ2
      Related
      ENSP00000498284.1, ENST00000651590.1
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 223
      Tropomyosin

    18. NM_001365781.2 → NP_001352710.1  tropomyosin alpha-1 chain isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC079328
      UniProtKB/TrEMBL
      Q1ZYL5
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 246
      Tropomyosin

    19. NM_001365782.1 → NP_001352711.1  tropomyosin alpha-1 chain isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC079328
      Consensus CDS
      CCDS92012.1
      UniProtKB/TrEMBL
      A0A494C0I0, H0YKJ4
      Related
      ENSP00000452830.2, ENST00000558910.3
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 246
      Tropomyosin; Tropomyosin

    20. NM_001407322.1 → NP_001394251.1  tropomyosin alpha-1 chain isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC079328

    21. NM_001407323.1 → NP_001394252.1  tropomyosin alpha-1 chain isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC079328

    22. NM_001407324.1 → NP_001394253.1  tropomyosin alpha-1 chain isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC079328
      Related
      ENSP00000519303.1, ENST00000714013.1

    23. NM_001407325.1 → NP_001394254.1  tropomyosin alpha-1 chain isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC079328
      Related
      ENST00000560131.2

    24. NM_001407326.1 → NP_001394255.1  tropomyosin alpha-1 chain isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC079328
      UniProtKB/TrEMBL
      A0AAQ5BHC3

    25. NM_001407327.1 → NP_001394256.1  tropomyosin alpha-1 chain isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC079328

    26. NM_001407328.1 → NP_001394257.1  tropomyosin alpha-1 chain isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC079328

    27. NM_001407329.1 → NP_001394258.1  tropomyosin alpha-1 chain isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC079328

    28. NM_001407330.1 → NP_001394259.1  tropomyosin alpha-1 chain isoform Tpm1.5cy

      Status: REVIEWED

      Source sequence(s)
      AC079328
      Consensus CDS
      CCDS10181.1
      UniProtKB/TrEMBL
      A0A0K0K1I0

    29. NM_001407331.1 → NP_001394260.1  tropomyosin alpha-1 chain isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC079328

    30. NM_001407332.1 → NP_001394261.1  tropomyosin alpha-1 chain isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC079328

    31. NM_001407333.1 → NP_001394262.1  tropomyosin alpha-1 chain isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC079328
      UniProtKB/TrEMBL
      A0A0S2Z4G6, A0AAQ5BH79, H0YL52

    32. NM_001407334.1 → NP_001394263.1  tropomyosin alpha-1 chain isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC079328

    33. NM_001407335.1 → NP_001394264.1  tropomyosin alpha-1 chain isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC079328

    34. NM_001407336.1 → NP_001394265.1  tropomyosin alpha-1 chain isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC079328

    35. NM_001407337.1 → NP_001394266.1  tropomyosin alpha-1 chain isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC079328

    36. NM_001407338.1 → NP_001394267.1  tropomyosin alpha-1 chain isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC079328

    37. NM_001407340.1 → NP_001394269.1  tropomyosin alpha-1 chain isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC079328
      Consensus CDS
      CCDS92011.1
      UniProtKB/TrEMBL
      B7Z596
      Related
      ENSP00000453724.1, ENST00000560959.5

    38. NM_001407341.1 → NP_001394270.1  tropomyosin alpha-1 chain isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC079328

    39. NM_001407342.1 → NP_001394271.1  tropomyosin alpha-1 chain isoform 40

      Status: REVIEWED

      Source sequence(s)
      AC079328

    40. NM_001407344.1 → NP_001394273.1  tropomyosin alpha-1 chain isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC079328
      UniProtKB/TrEMBL
      Q1ZYL5

    RNA

    1. NR_176337.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328
      Related
      ENST00000558347.5

    2. NR_176338.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328
      Related
      ENST00000559831.6

    3. NR_176339.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328

    4. NR_176340.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328

    5. NR_176341.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328

    6. NR_176342.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328

    7. NR_176343.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328

    8. NR_176344.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328

    9. NR_176345.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328
      Related
      ENST00000714016.1

    10. NR_176346.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328

    11. NR_176347.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328

    12. NR_176348.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328
      Related
      ENST00000644204.1

    13. NR_176349.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328

    14. NR_176350.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328
      Related
      ENST00000558544.5

    15. NR_176351.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328

    16. NR_176352.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328

    17. NR_176353.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079328
      Related
      ENST00000705544.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      63042747..63071915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433001.1 → XP_047288957.1  tropomyosin alpha-1 chain isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      60846575..60875760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378740.1 → XP_054234715.1  tropomyosin alpha-1 chain isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09493.2 GenPept UniProtKB/Swiss-Prot:P09493

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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