5PTASE13 Endonuclease/exonuclease/phosphatase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: 5PTASE13
Official Full Name: Endonuclease/exonuclease/phosphatase family protein
Primary source: TAIR:AT1G05630
Locus tag: AT1G05630
See related: Araport:AT1G05630
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: Arabidopsis thaliana inositol-polyphosphate 5-phosphatase 13; AT5PTASE13; F3F20.8; F3F20_8; inositol-polyphosphate 5-phosphatase 13
Summary: Encodes an inositol polyphosphate 5-phosphatase with phosphatase activity toward only Ins(1,4,5)P3. Induced in response to ABA and wounding treatments. Expressed in young seedlings and flowers, while no transcripts were detectable in maturated roots, stems, and rosette leaves Modulates the development of cotyledon veins through its regulation of auxin homeostasis. Involved in blue light light#Aeistimulated increase in cytosolic calcium ion.
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Genomic context

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See 5PTASE13 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 10

Sequence:: Chromosome: 1; NC_003070.9 (1682224..1687363)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

5PT13 deficiency synergistically enhances precocious pollen germination, and Ins(1,4,5)P3 basal level/cytosolic [Ca2+] is increased in 5pt12 and 5pt12 5pt13 mutants. [5PT13]
Title: Inositol polyphosphate 5-phosphatase-controlled Ins(1,4,5)P3/Ca2+ is crucial for maintaining pollen dormancy and regulating early germination of pollen.
Arabidopsis 5PTase13 functions in root gravitropism by regulating vesicle trafficking and gravity-induced auxin redistribution.
Title: The role of Arabidopsis 5PTase13 in root gravitropism through modulation of vesicle trafficking.
The WD40 repeat region of 5PTase13 interacts with the sucrose nonfermenting-1-related kinase, and loss of function in 5PTase13 leads to nutrient level-dependent reduction of root growth, along with abscisic acid (ABA) and sugar insensitivity.
Title: Interaction of the WD40 domain of a myoinositol polyphosphate 5-phosphatase with SnRK1 links inositol, sugar, and stress signaling.
Data suggest that 5PTase13 antagonizes PHOT1-mediated effects on calcium signaling under blue light.
Title: An inositol polyphosphate 5-phosphatase functions in PHOTOTROPIN1 signaling in Arabidopis by altering cytosolic Ca2+.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001035899.2

Supported by ESTs:

NM_001331561.1

Supported by ESTs:

NM_100443.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,4,5-trisphosphate 5-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-polyphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gravitropism	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inositol phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular auxin homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phloem or xylem histogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in pollen germination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to blue light	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to blue light	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to carbohydrate	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to nutrient	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to wounding	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sugar mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Endonuclease/exonuclease/phosphatase family protein

NP_001030976.1

5PTASE13; CONTAINS InterPro DOMAIN/s: Inositol polyphosphate related phosphatase (InterPro:IPR000300), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), Endonuclease/exonuclease/phosphatase (InterPro:IPR005135); BEST Arabidopsis thaliana protein match is: endonuclease/exonuclease/phosphatase family protein (TAIR:AT2G31830.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_172054.3

5PTASE13; CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), Inositol polyphosphate related phosphatase (InterPro:IPR000300), WD40 repeat (InterPro:IPR001680), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), Endonuclease/exonuclease/phosphatase (InterPro:IPR005135); BEST Arabidopsis thaliana protein match is: endonuclease/exonuclease/phosphatase family protein (TAIR:AT2G31830.1); Has 2865 Blast hits to 2115 proteins in 235 species: Archae - 0; Bacteria - 18; Metazoa - 1064; Fungi - 695; Plants - 755; Viruses - 0; Other Eukaryotes - 333 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

1682224..1687363

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100443.5 → NP_172054.3 Endonuclease/exonuclease/phosphatase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_172054.3

Status: REVIEWED

UniProtKB/TrEMBL

A0A654E8H6

Conserved Domains (5) summary

cd09074
Location:571 → 951

INPP5c; Catalytic domain of inositol polyphosphate 5-phosphatases

COG2319
Location:164 → 374

WD40; WD40 repeat [General function prediction only]

pfam14655
Location:491 → 523

RAB3GAP2_N; Rab3 GTPase-activating protein regulatory subunit N-terminus

sd00039
Location:446 → 474

7WD40; WD40 repeat [structural motif]

cl02567
Location:207 → 294

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001035899.2 → NP_001030976.1 Endonuclease/exonuclease/phosphatase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001030976.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4IAA0, Q712D7, Q9SYK4

UniProtKB/TrEMBL

A0A654E8H6

Conserved Domains (5) summary

cd09074
Location:571 → 917

INPP5c; Catalytic domain of inositol polyphosphate 5-phosphatases

COG2319
Location:164 → 374

WD40; WD40 repeat [General function prediction only]

pfam14655
Location:491 → 523

RAB3GAP2_N; Rab3 GTPase-activating protein regulatory subunit N-terminus

sd00039
Location:446 → 474

7WD40; WD40 repeat [structural motif]

cl02567
Location:207 → 294

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001331561.1 → NP_001322440.1 Endonuclease/exonuclease/phosphatase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WMF7, A0A1P8AU01